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Year : 1995  |  Volume : 38  |  Issue : 1  |  Page : 25-32

Nucleolar organizer regions in pituitary adenomas.


Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India

Correspondence Address:
V V Radhakrishnan
Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India

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Source of Support: None, Conflict of Interest: None


PMID: 8919466

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In this study, thirty-two non-functional and eighteen functional pituitary adenomas were analysed for the presence of argyrophilic nucleolar organizer regions (Ag-NORs) in paraffin sections, using an one-step silver-colloidal staining method. Differences in the mean Ag-NOR numbers of functional pituitary adenomas were statistically significant than those of non-functional pituitary adenomas. It is being emphasised that evaluation of Ag-NOR count is a more reliable index than the presence of mitotic figures in predicting the proliferative activity as well as possibility of recurrence in a patient with pituitary adenoma.


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