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Indian Journal of Pathology and Microbiology
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Year : 1995  |  Volume : 38  |  Issue : 4  |  Page : 427-33

Epithelioid granulomas in Hodgkin's disease--prognostic significance.


Department of Pathology, Christian Medical College & Hospital, Ludhiana, Punjab

Correspondence Address:
R Chopra
Department of Pathology, Christian Medical College & Hospital, Ludhiana, Punjab

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Source of Support: None, Conflict of Interest: None


PMID: 9726157

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Prognostic significance of non-caseating epithelioid granulomas in association with Hodgkin's disease has been studied. Such granulomas were found in 15 of the total of 104 cases of Hodgkin's disease encountered between Jan. 1981 and June 1990. These 15 patients were compared with 30 concurrent patients of Hodgkin's disease who did not have associated granulomas. All the patients were initially staged, treated and followed up for a period of two years. There was no significant difference in overall survival rate between the granuloma group and the control group. However, in relapse free survival rate in advanced stages of the disease (III & IV), although the difference between granuloma group and the control group was not statistically significant (p = 0.11), yet the relapse free survival curves revealed a tendency towards better survival with lesser number of relapses and longer remissions in granuloma group.


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