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Indian Journal of Pathology and Microbiology
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Year : 1996  |  Volume : 39  |  Issue : 1  |  Page : 19-25

HLA class-I and class-II antigen association in rheumatoid arthritis at Varanasi, India.


Advance UGC Immunodiagnostic Training & Research Centre, Banaras Hindu University, Varanasi

Correspondence Address:
V Agrawal
Advance UGC Immunodiagnostic Training & Research Centre, Banaras Hindu University, Varanasi

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Source of Support: None, Conflict of Interest: None


PMID: 8755127

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Clinical presentation of rheumatoid arthritis (RA) and its severity differs in different races. Genetic factors play a significant role in its predeliction. The present study was undertaken to find out association of HLA class I and class II antigens with rheumatoid arthritis prevalent in Asian Indians residing at Varanasi. Ninety rheumatoid arthritis patients strictly fulfilling American Rheumatism Association criteria were screened for prevalent HLA class I and class II antigen by Terasaki Microlympho-cytotoxicity test. Results were compared with 100 healthy controls and 35 Seronegative Spondyloarthritides cases (SSA). Rheumatoid arthritis patients showed increased frequency of HLA-A2 and B40 antigens compared to healthy controls (p < .001). SSA patients showed significantly increased Phenotype frequency (PF) of HLA-B27 (p < .0001) and B40 (p < .001). Significant detection of HLA-A2 exclusively in RA patients suggests a more positive association of A2 in rheumatoid arthritis at Varanasi. HLA-B40 could not be attributed absolute significance of association with SSA or RA as it showed increased frequency in both diseases.


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