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Year : 1997  |  Volume : 40  |  Issue : 3  |  Page : 351-4

Study of association of Epstein Barr-virus with Hodgkin's disease.


Department of Pathology, Dr. A.L. Mudaliar Postgraduate Institute of Basic Medical Science, University of Madras, Taramani

Correspondence Address:
K Radha
Department of Pathology, Dr. A.L. Mudaliar Postgraduate Institute of Basic Medical Science, University of Madras, Taramani

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Source of Support: None, Conflict of Interest: None


PMID: 9354006

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Epstein Barr-Virus (EBV) is a lymphotropic herpes virus, well recognised for its oncogenic properties. In recent years substantial evidence has accumulated supporting a role for EBV in the pathogenesis of Hodgkin's disease. The epidemiologic and histologic features of Hodgkin's disease (HD) have long indicated a possible infective cause. Our study involves the detection of the EBV encoded latent membrane protein 1 (LMP-1) in 45 cases of Hodgkin's disease using immunohistochemical methods. In this study we detected LMP-1 positivity in the Reed-Sternberg and Hodgkin's cells in 31% of cases of HD. In mixed cellularity the positivity was 21.7% while nodular sclerosis exhibited positivity of 50% of the cases. The lymphocyte depletion subtype showed 100% positivity. All cases of lymphocyte predominance and the single unclassified case were negative for LMP. The demonstration of LMP-1 in Hodgkin's disease has important implications since it is one of the latent gene products which produces B Lymphocyte transformation.


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