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Indian Journal of Pathology and Microbiology
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Year : 1998  |  Volume : 41  |  Issue : 4  |  Page : 423-6

A simple screening test for the detection of heterozygous beta thalassemia.


Department of Laboratory Medicine, Safdarjung Hospital, New Delhi

Correspondence Address:
A A Thool
Department of Laboratory Medicine, Safdarjung Hospital, New Delhi

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Source of Support: None, Conflict of Interest: None


PMID: 9866902

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Beta-Thalassemia is prevalent in a high frequency of 5-15% in selected geographical areas and ethnic communities. There is need to screen large populations for the heterozygotes of beta-Thalassemia. We have evaluated NESTROFT (Naked eye single tube red cell osmotic fragility test) with 0.36% buffered saline in this study. Of the population screened, 42 cases were positive with NESTROFT, of which 40 were positive with the confirmatory test for beta-Thalassemia. This implies a positive predictive value and specificity of 100%, negative predictive value of 83.3% and sensitivity of 95.2%.


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