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Indian Journal of Pathology and Microbiology
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Year : 2001  |  Volume : 44  |  Issue : 1  |  Page : 9-12

A study of the haematologic spectrum of myelodysplastic syndrome.


Department of Pathology, Kottayam Medical College, Kottayam

Correspondence Address:
J Kini
Department of Pathology, Kottayam Medical College, Kottayam

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Source of Support: None, Conflict of Interest: None


PMID: 12561987

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In 31 patients of myelodysplastic syndrome, RAEB-t was the commonest subtype (29%), and RARS, the lease common (6.4%); 19.4% were characterised as the unclassifiable (UC) group. Pallor was the dominant sign (90.3%). Low haemoglobin in RA & RARS (p<0.05), thrombocytopenia in RAEB-t (p<0.01) and high leuco/monocyte counts in CMML (p<0.001) were observed. Neutropenia occurred most frequently in RAEB & RAEB-t and circulating blasts in all cases of RAEB-t and CMML. Bicytopenia was the commonest finding (58.1%) and pancytopenia the least (16.1%). 84% of marrows were hypercellular and trilineage dysplasia was seen in 68% of patients. Megaloblastoid dyserythropoiesis was the predominant feature in all cases, dysgranulopoiesis in all cases of RAEB, RAEB-t and CMML, and micromegokaryocytes in all cases of RARS, RAEB & CMML were seen. RAEB-t and RAEB (33.3% each) were the predominant groups which progressed to leukemia, FAB AML-M2, being the commonest type (60%).


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