Indian Journal of Pathology and Microbiology
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Year : 2001  |  Volume : 44  |  Issue : 2  |  Page : 163-7

Nerve cell markers in ossifying fibromyxoid tumour of soft parts.


Department of Pathology, BYL Nair Ch Hospital, Mumbai

Correspondence Address:
T Shet
Department of Pathology, BYL Nair Ch Hospital, Mumbai

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Source of Support: None, Conflict of Interest: None


PMID: 11883138

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Reported herein are two benign ossifying fibromyxoid tumors (OFMTs) of the soft tissues in axilla and terminal phalanx respectively. Both cases on immunohistochemistry (IHC) showed reactivity for vimentin, S-100 protein and glial fibrillary acidic protein (GFAP) antibodies. In addition, a focal/diffuse strong positivity for neurofilament (NF) and neuron specific enolase (NSE) was observed. Electron microscopy in one instance revealed abundant intermediate filaments, primitive cell junctions and a focally present external lamina. In the light of nerve cell differentiation of these tumors and the similarity of IHC profile and EM features of OFMT to a poorly differentiated malignant peripheral nerve sheath tumor (MPNST); it is suggested that OFMT is a variably differentiated PNST rather than a simple Schwannian neoplasm as is believed.


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