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Indian Journal of Pathology and Microbiology
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Year : 2002  |  Volume : 45  |  Issue : 3  |  Page : 355-7

Congenital leukaemia in Down Syndrome--a case report.


Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry

Correspondence Address:
Moatoshi Aier
Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry

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Source of Support: None, Conflict of Interest: None


PMID: 12785186

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A 17 days old male infant, who had features of Down Syndrome, presented with fever, refusal to feed and seizures. He had papular, crusted skin lesions, moderate hepatosplenomegaly and a rapid downhill course. Peripheral blood and bone marrow aspirate showed features of acute leukaemia. Congenital Leukaemia is a rare malignancy associated with a very poor prognosis. Paradoxically, many cases of Congenital Leukaemia, especially in infants with Down Syndrome, show spontaneous remission.


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