Indian Journal of Pathology and Microbiology
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Year : 2006  |  Volume : 49  |  Issue : 1  |  Page : 37-9

Anti Kell allo-antibody in a thalassaemic.


Department of Transfusion Medicine and Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh

Correspondence Address:
B Thakral
Department of Transfusion Medicine and Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh

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Source of Support: None, Conflict of Interest: None


PMID: 16625974

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We describe a case of incidental detection of anti Kell antibody in a child with transfusion dependent thalassaemia. Kell antibody detection may be missed by routine indirect antiglobulin test (IAT) crossmatch procedure because of low prevalence of Kell antigen in the general population. A false negative result can be avoided by using sensitive cross matching techniques and screening cells representing antigens in homozygous state, against all clinically significant antibodies. A transfusion alert card describing the nature of antibody and future transfusion policy should be given to such allo-immunized patients.


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