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Year : 2008  |  Volume : 51  |  Issue : 3  |  Page : 460-461
Prevalence of HCV and HBV infection in liver disorders in the Aligarh region of western Uttar Pradesh


1 Department of Microbiology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
2 Department of Medicine, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

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How to cite this article:
Ali S, Shukla I, Malik A, Rizvi M, Ajmal M R. Prevalence of HCV and HBV infection in liver disorders in the Aligarh region of western Uttar Pradesh. Indian J Pathol Microbiol 2008;51:460-1

How to cite this URL:
Ali S, Shukla I, Malik A, Rizvi M, Ajmal M R. Prevalence of HCV and HBV infection in liver disorders in the Aligarh region of western Uttar Pradesh. Indian J Pathol Microbiol [serial online] 2008 [cited 2019 Dec 16];51:460-1. Available from: http://www.ijpmonline.org/text.asp?2008/51/3/460/42540


Sir,

In industrialized countries hepatitis C virus (HCV) accounts for 20% of acute hepatitis, 70% of chronic hepatitis, 40% end stage cirrhosis and 60% hepatocellular carcinoma. [1] HCV is the dominant cause of non-alcoholic chronic liver disease (CLD) in several parts of the world, [2],[3] whereas in our country, there are conflicting reports. Some report hepatitis B while others hepatitis C viruses as the most important infection in CLD patients. There is a paucity of data pertaining to HBV and HCV infection in different liver diseases emanating from this region. We planned a prospective study to assess the prevalence of HBV and HCV in various liver disorders in Aligarh and its neighboring regions. Identification of risk factors in acquisition of HBV infection was also carried out. The study group comprised of 300 patients attending the Outpatient and Inpatient Departments of Medicine diagnosed with acute viral hepatitis, fulminant hepatitis, chronic hepatitis, cirrhosis of liver, alcoholic cirrhosis and hepatocellular carcinoma. A control group comprised of 30 healthy individuals. Serum samples were screened for the presence of Hepatitis B surface antigen (HbsAg) by latex agglutination and confirmed by enzyme linked immunosorbent assay (ELISA). Anti-HCV antibodies were detected by a 3rd generation HCV ELISA kit. In our study, 12 (4%) cases were positive for HCV antibodies. The distribution of anti-HCV ELISA-positive patients in relation to type of liver disease is shown in [Table 1]. Among these HCV-positive patients, 3 (25%) had acute viral hepatitis, while an overwhelming majority 9 (75%) cases were patients of CLD. Patients with cirrhosis [6 (66%)] predominated among the cases with CLD followed by cases with chronic viral hepatitis [2 (22.2%)] and cases with hepatocellular carcinoma [1 (11.1%)].

Of the 300 patients, 110 (36.7%) were positive for HBV [Table 1]. In this study, an equal number [55 (50%)] of patients presented with both acute and CLD. Patients with acute viral hepatitis [39 (35.4%)] represented the largest subset of cases with HBV infection, followed by cirrhosis in 32 (29%) and chronic viral hepatitis in 21 (19%) cases. There were 16 (14.5%) cases of hepatic encephalopathy and 2 (1.8%) cases of hepatocellular carcinoma. There was one case of co-infection of HBV and HCV (0.3%). There were 3 (25%) fatalities among the HCV-positive patients and 19 (17.27%) among HBV-positive cases [Table 1]. The commonest risk factors for transmission of HBV and HCV infection in our study was found to be needle prick injuries followed by tooth extraction and blood transfusion.

Our results demonstrate that HBV is the most prevalent viral infection associated with liver disorders in this region. A low prevalence of HCV infection (4%) was seen in Aligarh and its surrounding region. Prevalence levels similar to ours (2.5%) have been reported from South India. [4] On the contrary, a very high prevalence (37.5%) of HCV has been reported from Delhi by Singh et al ., [5] and an extremely low level 0.2% has been reported from Western India. [6]

 
   References Top

1.EASL International Consensus Conference on hepatitis C: Paris, 26-27 February 1999. Consensus statement. J Hepatol 1999;31:3-8.  Back to cited text no. 1    
2.Benvegnu L, Pontisso P, Cavalletto D, Noventa F, Chemello L, Alberti A. Lack of correlation between hepatitis C virus genotypes and clinical courses of hepatitis C virus-related cirrhosis. Hepatology 1997;25:211-5.  Back to cited text no. 2    
3.Sarin SK, Guptan RC, Banerjee K, Khandekar P. Prevalence of hepatitis C viral infection in patients with non-alcoholic chronic liver in India. J Assoc Physicians India 1996;44:243-5.  Back to cited text no. 3  [PUBMED]  
4.Sumathy S, Valliammai J, Thyagarajan SP, Malathy S, Madanagopaalan N, Shankarnarayan V, et al . Prevalence of hepatitis C virus infection in liver diseases, renal diseases and voluntary blood donors in South India. Indian J Med Microbial 1993;11:291-7.  Back to cited text no. 4    
5.Singh V, Yachha SK, Thapa BR, Mehta S. Antibiotics to hepatitis C virus (anti-HCV) in children. Indian Pediatr 1991;28:1532-3.  Back to cited text no. 5  [PUBMED]  
6.Arankelle VA, Chadha MS, Jha J, Amarapurkar DN, Banerjee K. Prevalence of anti HCV antibodies in Western India. Indian J Med Res 1995;101:91-3.  Back to cited text no. 6    

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Correspondence Address:
Indu Shukla
Department of Microbiology, JN Medical College, Aligarh Muslim University, Aligarh - 202 002, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.42540

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