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Indian Journal of Pathology and Microbiology
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CASE REPORT
Year : 2008  |  Volume : 51  |  Issue : 4  |  Page : 512-514

Endometrial intraepithelial carcinoma: A case report and brief review


1 Department of Cellular Pathology, The Princess Alexandra Hospital, Harlow, Essex CM20 1QX, United Kingdom
2 Department of Pathology, Dr. Ram Manohar Lohia Hospital, New Delhi, India

Correspondence Address:
Manisha Ram
85, Wedgewood Drive, Church Langley, Harlow, CM17 9PY
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.43744

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This case report describes the precursor lesion of uterine papillary serous carcinoma (UPSC). A 65-year-old post-menopausal female presented with prolapse and vaginal discharge and underwent a hysterectomy revealing an atrophic endometrium, highly atypical endometrial glands, the lining cells of which showed pseudostratification, hobnailing, a high nuclear to cytoplasmic ratio, and prominent nucleoli. A p53 immunoreactivity score of 8 and a MIB-1 index of 80% was obtained leading to a diagnosis of endometrial intraepithelial carcinoma (EIC). Since serous EIC is commonly associated with extra-uterine serous carcinoma, it is a uniquely aggressive precursor lesion. Molecular studies support the hypothesis that EIC is a precursor of both uterine and extra-uterine invasive serous carcinomas. This is why the treatment protocol for EIC cases is total abdominal hysterectomy (TAH), accompanied by a staging procedure. In our patient, EIC was limited to the endometrium; associated with an excellent clinical outcome.


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