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Indian Journal of Pathology and Microbiology
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ORIGINAL ARTICLE
Year : 2009  |  Volume : 52  |  Issue : 2  |  Page : 189-190

A simple broth-disk method to determine the minimum inhibitory concentration of ceftriaxone on Salmonella enterica serovar typhi and paratyphi


Department of Microbiology, Kasturba Medical College, Mangalore - 575 001, India

Correspondence Address:
K Gopalkrishna Bhat
Department of Microbiology, Kasturba Medical College, Mangalore - 575 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.48913

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Background and Purpose: Resistance to fluoroquinolones and cephalosporins is a major problem with Salmonella enterica serovar Typhi and Paratyphi. An accurate determination of antibiotic susceptibility requires tests for minimum inhibitory concentration (MIC) of antibiotics. We describe a simple broth-disk method to determine the MIC of ceftriaxone on S. typhi and S. paratyphi . Materials and Methods: Sixteen strains of S. typhi and two strains each of S. paratyphi A and S. paratyphi B were used in the study. The MIC of ceftriaxone was determined using the simple broth-disk method and the conventional broth macrodilution method and the results were compared. Results: All salmonella strains were susceptible to ceftriaxone. The results of the broth-disk and the conventional broth macrodilution method were similar. Conclusion: The broth-disk method is a simple, reliable and cost-effective method to determine the MIC of ceftriaxone on S. typhi and S. paratyphi A.


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