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CASE REPORT
Year : 2009  |  Volume : 52  |  Issue : 3  |  Page : 403-404

Endodermal sinus tumor of the vagina in children: A report of two cases


1 Department of Pathology, North Bengal Medical College and Hospital, Sushrutanagar, Darjeeling, India
2 Department of Gynecology and Obstetrics, North Bengal Medical College and Hospital, Sushrutanagar, Darjeeling, India

Correspondence Address:
Mimi Gangopadhyay
Department of Pathology, North Bengal Medical College and Hospital, Sushrutanagar, Darjeeling
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.55008

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Malignant tumors of the vagina in infants and children are rare, with primary germ cell tumor (endodermal sinus tumor [EST]) being rarer, which carries a dismal prognosis. This tumor is often clinically mistaken as botryoid rhabdomyosarcoma and, on histopathological examination, is often misdiagnosed as clear cell adenocarcinoma. Two cases of EST of the vagina in infants aged 9 and 17 months are reported. Both the patients presented with bleeding per vagina and clinically and by ultrasonography were diagnosed as sarcoma botryoides. Both were diagnosed as primary yolk sac tumors. The serum alfa fetoprotein (AFP) level was 4325 and 9328 ng/ml, respectively. One patient aged 9 months expired 2 months after receiving chemotherapy. The other, aged 17 months, was given chemotherapy followed by surgery with reduction of the AFP levels.


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