Indian Journal of Pathology and Microbiology
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CASE REPORT
Year : 2009  |  Volume : 52  |  Issue : 4  |  Page : 568-570

Monophasic synovial sarcoma of tongue


Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India

Correspondence Address:
R F Chinoy
Annexe Building, 8th Floor, Dr. Ernest Borges Road, Parel, Mumbai-400 012
India
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DOI: 10.4103/0377-4929.56167

PMID: 19805977

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Synovial sarcoma is a well defined morphologic entity extensively researched in literature. Synovial sarcoma displays a wide spectrum of clinical presentations and histologic appearances that may give rise to diagnostic dilemmas. One such unusual site in the head and neck area is the tongue. We report a case of monophasic synovial sarcoma of the tongue in a 22-year-old male. Microscopically, this tumor mimicked a poorly differentiated carcinoma which is more common at this site though the patient was young for this type of tumor. On immunohistochemistry, neoplastic cells were positive for cytokeratin, vimentin, calponin, CD99 and bcl2. Molecular studies - viz. reverse transcriptase polymerase chain reaction revealed a SYT-SSX translocation clinching the diagnosis. This paper highlights the immunohistochemistry profile and SYT-SSX translocation which helped arrive at an accurate diagnosis only because the index of suspicion for a monophasic synovial sarcoma is high.


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