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ORIGINAL ARTICLE
Year : 2010  |  Volume : 53  |  Issue : 1  |  Page : 54-56

Significance of preoperative thrombocytosis in epithelial ovarian cancer


1 Department of Pathology, St. John's Medical College and Hospital, Sarjapur Road, Bangalore - 560 034, Karnataka, India
2 Department of Gynecologic Oncology, St. John's Medical College and Hospital, Sarjapur Road, Bangalore - 560 034, Karnataka, India
3 Department of Clinical Pathology, St. John's Medical College and Hospital, Sarjapur Road, Bangalore - 560 034, Karnataka, India

Correspondence Address:
Julian A Crasta
Department of Pathology, St. John's Medical College, Bangalore-560 034, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.59184

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Background: Reactive thrombocytosis is reported in a variety of solid tumors. A few studies have documented preoperative thrombocytosis in ovarian cancer and identified it as a marker of aggressive tumor biology. Aim: To study the incidence of preoperative thrombocytosis (platelets greater than 400x10) in epithelial ovarian cancer and its association with other clinicopathologic factors. Materials and Methods: Sixty-five patients with invasive ovarian epithelial cancer were retrospectively reviewed and analyzed for the association preoperative thrombocytosis with other clinical and histopathological prognostic factors. Means were analyzed by Student's t test; proportions were determined by Chi-square analysis. Results: Twenty of 65 (37.5%) patients had thrombocytosis at primary diagnosis. Patients with preoperative thrombocytosis were found to have lower hemoglobin (P < 0.0002), more advanced stage disease (P < 0.05) and higher grade tumors (P < 0.02). Patients with thrombocytosis had greater likelihood of subpotimal cytoreduction. Conclusions: Preoperative thrombocytosis is a frequent finding in ovarian carcinomas and their association with advanced stage disease and higher grade denotes that platelets play a role in the tumor growth and progression.


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