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Indian Journal of Pathology and Microbiology
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ORIGINAL ARTICLE
Year : 2010  |  Volume : 53  |  Issue : 4  |  Page : 696-698

Comparative analysis of protein structure of common Hb Q variants


Department of Pathology, Super Religare Laboratories Ltd., Fortis Escorts Hospital and Research Centre, Faridabad, India

Correspondence Address:
Amit K Yadav
Department of Pathology, Super Religare Laboratories Ltd., Fortis Escorts Hospital and Research Centre, Faridabad
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.72039

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Context: Hemoglobin (Hb) Q variant is a group of hemoglobinopathies prevalent in south, south-east and western Asia. The primary structure of all of these molecules is well known. However, very little is known about the secondary and tertiary structures of these molecules. Therefore, a study of their secondary and tertiary structures is needed. Aim: The study was aimed at investigating the secondary and tertiary structures of common Hb Q variants using bioinformatics tool. Settings and Design: The secondary and tertiary structures of common Hb Q variants were evaluated using NNPREDICT server and CPHmodels 2.0 server, respectively. Materials and Methods: Amino acid sequence of alpha globin chain was searched using ExPASY and was used for further mutation to Hb Q variants. The derived sequences were further analyzed using NNPREDICT server and CPHmodels 2.0 server to calculate their secondary and tertiary structures, respectively. These were then compared and any differences noted. Results: It was observed that there is no difference between the predicted secondary structures of normal alpha globin and Hb Q-India. Hb Q-Iran carries an extra helix while Hb Q-Thailand carries two extra helices. The results of tertiary structure prediction also support these findings. Conclusions: Differences in secondary and tertiary structure of various Hb Q variants have been observed in the present study. The study provides valuable data for better understanding of these uncommon hemoglobinopathies.


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