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CASE REPORT
Year : 2011  |  Volume : 54  |  Issue : 1  |  Page : 176-179

CALLA negative precursor B lymphoblastic leukemia with MLL gene translocation and an unusual FISH signal pattern


1 Department of Laboratory Medicine, Indo-American Cancer Institute and Research Centre, Hyderabad - 500 034, India
2 Department of Medical Oncology, Indo-American Cancer Institute and Research Centre, Hyderabad - 500 034, India

Correspondence Address:
Sandhya G Devi
Department of Laboratory Medicine, Indo-American Cancer Institute and Research Centre, Road No.14, Banjara Hills, Hyderabad - 500 034
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.77396

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Rearrangements of the mixed lineage leukemia (MLL) gene at 11q23 commonly occur in infants with CALLA negative B lymphoblastic leukemia (B-ALL). Most often, these are detected by conventional karyotyping; however, fluorescent in-situ hybridization (FISH) with the help of a dual-color break-apart probe is used to identify cryptic translocations. When there is an MLL gene translocation, the usual FISH signal pattern is 1 red-1 green-1 yellow fusion signal pattern. We present a case of an infant with CALLA negative precursor B-ALL with a characteristic translocation t(4;11) (q21;q23), however, with an unusual MLL FISH signal pattern.


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