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Year : 2011  |  Volume : 54  |  Issue : 1  |  Page : 208-209
Peritoneal malignant psammomatous mesothelioma


1 Institute of Anatomic Pathology S.Maria del Carmine Hospital Rovereto, Rovereto, Trento, Italy
2 Department of Radiology, Budrio Hospital, via Benni 44, 40054 Budrio (BO), Italy

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Date of Web Publication7-Mar-2011
 

How to cite this article:
Pusiol T, Zorzi MG, Morichetti D, Piscioli I. Peritoneal malignant psammomatous mesothelioma. Indian J Pathol Microbiol 2011;54:208-9

How to cite this URL:
Pusiol T, Zorzi MG, Morichetti D, Piscioli I. Peritoneal malignant psammomatous mesothelioma. Indian J Pathol Microbiol [serial online] 2011 [cited 2019 Nov 17];54:208-9. Available from: http://www.ijpmonline.org/text.asp?2011/54/1/208/77409


Psammoma bodies (PBs) are concentrically laminated calcific spherules that occasionally appear cracked (psammos ["sand"] + oma ["tumor"]). PBs are observed most commonly in papillary thyroid carcinoma, meningioma, and papillary serous cystadenocarcinoma of ovary. PBs have been reported rarely in other neoplasms and benign non-neoplastic conditions. We report one case of Peritoneal malignant mesothelioma (PMM) with massive deposition of PBs with emphasis to biological significance of PBs and diagnostic differentiation with similar neoplasms.

A 72-year-old man presented with abdominal swelling and marked weight loss. No history of exposure to asbestos was found. Abdominal ultrasound revealed abundant perihepatic, perisplenic, and pelvic fluid. Contrast enhanced computed tomography showed fluid diffuse in peritoneal recesses, thick septa with micronodules in the greater omentum, and adjacent enhancement of the thickened peritoneum [Figure 1]. Malignant cells were found in the cytologic analysis of ascites. The explorative laparoscopy showed diffuse minute parietal peritoneal nodules. The peritoneal biopsy revealed a superficial papillary growth of malignant epithelial-like cells with diffuse involvement of submesothelial tissues. Massive deposition of PBs was observed [Figure 2] a and b. Nuclear and cytoplasmic calretinin immunoreactivities were present in neoplastic cells [Figure 3], along with membranous D2-40 [Figure 4] and membranous/cytoplasmic cytokeratin 5 staining. The patient was treated with chemotherapy (gemcitabine, vinorelbine, cisplatin).
Figure 1: Contrast-enhanced CT of the abdomen shows abundant peritoneal fluid in the left iliac fossa (*) and paracolic fluid in the right side (curved arrow); note the thick septa with micronodules in the greater omentum (arrows) and circumscribed enhancement of the thickened peritoneum (arrow head).

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Figure 2: (a) The peritoneal biopsy fragment shows massive deposition of psammoma bodies (HandE; ×25). (b) The superficial peritoneum shows a proliferation of malignant cells with the massive presence of psammoma bodies (H and E, ×100)

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Figure 3: Neoplastic cells show nuclear and cytoplasmic calretinin immunoreactivity.(IHC, ×200)

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Figure 4: A positive membranous staining with the D2-40 antibody is seen in neoplastic cells.(IHC, ×200)

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PMM is universally regarded as a fatal disease (median survival 6-12 months; mean symptoms-to survival time 345 days). [1] Diffuse malignant mesotheliomas have been divided into epithelioid, sarcomatoid, desmoplastic, and biphasic. PMMs are qualitatively similar to those occurring in the pleural cavity, but the relative proportions among the various types and the criteria used for differential diagnosis with metastatic carcinoma (ovary and lung respectively) are different. A precise diagnosis based on imaging findings alone is not possible. Furthermore, distinguishing a benign from a malignant process as well as a primary from a metastatic process is also challenging. Therefore, the definitive diagnosis of PMM depends on histological and immunohistochemical examinations. The frequency of PBs presence in PMMs is undetermined but certainly their presence is a very unusual finding.

Attanoos and Gibbs [2] reported that PBs may be seen in approximately 5% to 10% cases of PMMs. But these authors have not documented this finding with a series of cases or with citations reporting this value. In well-differentiated papillary mesothelioma of peritoneum, PBs have been described in 22% of the cases. [3] In the first report of this indolent, benign disease, the illustration of PBs showed only two psammoma bodies and documented that the presence of PBs is very limited. To date massive depositions of PBs have not been reported in PMM. The pathogenesis of the extensive presence of PBs is unknown. According to Das et al.[4] we believe that single necrotic cells constitute seed crystals that become incrusted with the mineral deposits and the progressive acquisition of outer layers may create its lamellated configurations. PBs may represent an active biologic process ultimately leading to degeneration/death of tumor cells and retardation of growth of the neoplasm. It may also serve as a barrier against the spread of tumor. Psammomatous MPM may simulate serous psammocarcinoma of the peritoneum. [5] In our case the immunophenotipic profile was conclusive of MM: neoplastic cells were positive for calretinin, CK5, and D2-40. [6] These antibodies are known to be highly sensitive and specific immunohistochemical markers of MM and permit to exclude serous psammocarcinoma of the peritoneum. The behavior of serous psammocarcinoma is more closely similar to borderline serous tumor than to serous carcinoma. Further studies are necessary to establish if massive deposition of PBs may define a new variant of PMM with a favorable impact to the prognosis of usual PMM, as well as in serous psammocarcinoma of the peritoneum.

 
   References Top

1.Cunha P, Luz Z, Seves I, Sousa C, Skiappa, Ribeiro L, et al. Malignant peritoneal mesothelioma - diagnostic and therapeutic difficulties. Acta Med Port 2002;15:383-6.  Back to cited text no. 1
    
2.Attanoos RL, Gibbs AR. Pathology of malignant mesothelioma. Histopathology 1997;30:403-18.  Back to cited text no. 2
    
3.Das DK. Psammoma body: A product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumour? Diagn Cytopathol 2009;37:534-41.  Back to cited text no. 3
    
4.Alanbay I, Dede M, Ustün Y, Karasahin E, Deveci S, Günhan O, et al . Serous psammocarcinoma of the ovary and peritoneum: Two case reports and review of the literature. Arch Gynecol Obstet 2009;279:931-6.  Back to cited text no. 4
    
5.King JE, Thatcher N, Pickering CA, Hasleton PS. Sensitivity and specificity of immunohistochemical markers used in the diagnosis of epithelioid mesothelioma: A detailed systematic analysis using published data. Histopathology. 2006;48:223-32.  Back to cited text no. 5
    
6.Ordóñez NG. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol 2005;36:372-80.  Back to cited text no. 6
    

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Correspondence Address:
Teresa Pusiol
Institute of Anatomic Pathology, S. Maria del Carmine Hospital Rovereto, Rovereto, Trento
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.77409

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  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

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