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Year : 2011  |  Volume : 54  |  Issue : 1  |  Page : 232-234
Extrauterine primary peritoneal endometriosis associated tumor of rectosigmoid


Department of Pathology, CHL-Apollo Hospitals, Near LIG Triangle, Indore, Madhya Pradesh - 452 018, India

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Date of Web Publication7-Mar-2011
 

How to cite this article:
Bhargava S, Kothari V. Extrauterine primary peritoneal endometriosis associated tumor of rectosigmoid. Indian J Pathol Microbiol 2011;54:232-4

How to cite this URL:
Bhargava S, Kothari V. Extrauterine primary peritoneal endometriosis associated tumor of rectosigmoid. Indian J Pathol Microbiol [serial online] 2011 [cited 2019 Nov 12];54:232-4. Available from: http://www.ijpmonline.org/text.asp?2011/54/1/232/77419


Sir,

A 46-year-old female, with history of hysterectomy 10 years ago, presented in 2009 with complaints of constipation of few months duration. Colonoscopy revealed an extra-mucosal stricture in sigmoid colon. The mucosa looked unremarkable. Computed tomography scan revealed two separate, intramural nodular masses in muscle and peritoneal coats with the intervening segment unremarkable. There also were innumerable smaller nodules all over the pelvic peritoneum, in general, and pouch of Douglas, in particular.

The affected segment was resected. The stricture areas showed two distinct nodular masses, measuring 4.0 and 2.5 cm in maximum dimension, respectively. Microscopically, the tumor cells were small, round, monomorphic like stromal cells of proliferative phase of endometrium. The tumor cell nodules were pushing tongue-like extensions into tissue spaces, and limited to muscle and peritoneal coats. Stroma showed spiral arterioles [Figure 1], [Figure 2] and [Figure 3]. Cells were CD10 positive, ER positive, PR positive, CD117 negative, Vimentin positive and SMA negative.

Diagnosis of classic type of endometrial stromal sarcoma (ESS) infiltrating a segment of sigmoid was obvious.
Figure 1: Tumor nodule showing a pushing border and infiltration is limited to peritoneum and muscle coat (H and E, ×40)

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Figure 2: Tumor cells' infiltration in muscle coat; mucosa and submucosa were free (H and E ×100)

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Figure 3: Small, round, monomorphic cells aggregating around spiral arterioles in the stroma (H and E ×600)

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Endometriosis associated intestinal tumors (EAIT) are seen as a rare complication of pelvic peritoneal endometriosis. Rectosigmoid wall is the most frequently infiltrated segment responsible for clinical symptoms.

EAIT are a spectrum of tumors varying from glandular to stromal elements of Mullerian duct origin, complicating endometriosis. Of these, endometroid adenocarcinoma is the most frequently seen and ESS the least. [1],[2]

Awareness of these tumors in a particular clinical setup needs to be appreciated. Preoperative clinical diagnosis is extremely difficult.

In a postmenopausal female, often giving a past history of hysterectomy, presenting with colonic complaints referable to extramucosal, intramural mass producing stricture deformity, EAIT needs to be considered vis-à-vis a primary colonic/mesenteric pathology.

Diagnosis of ESS is exclusively based on surgical pathological examination. Diagnosis of classic ESS on routine H and E sections offers no difficulty. The specific immunophenotype emphasizing ESS, namely, CD10 positive, ER and PR positive, CD 117 negative, offers additional help when ESS shows metaplastic changes including glandular and/or mesenchymal tissues. The immunophenotype also offers help in differentiation with the other look-alike tumors. [3],[4] Presence of high frequency of gene fusion of JAZFI-JJAZI as a result of t(7:17) (p15:q21), is a frequent, although nonuniform feature of ESS including its metaplastic variants. This may be applicable for diagnostic use in select situations. [5]


   Acknowledgment Top


We are grateful to Dr. Ruchi Sachdeva, Scientific Officer, Department of Pathology, CHL-Apollo Hospitals, Indore, Madhya Pradesh, India, for her technical help in the preparation of the manuscript.

 
   References Top

1.Yantiss RK, Clement PB, Young RH. Neoplastic and pre-neoplastic changes in gastrointestinal endometriosis: A study of 17 cases. Am J Surg Pathol 2000;24:513-24.  Back to cited text no. 1
[PUBMED]  [FULLTEXT]  
2.Slavin RE, Krum R, Van Dinh T. Endometriosis-associated intestinal tumors: A clinical and pathological study of 6 cases with a review of the literature. Hum Pathol 2000;31:456-63.  Back to cited text no. 2
[PUBMED]    
3.McCluggage WG, Ganesan R, Herrington CS. Endometrial stromal sarcomas with extensive endometrioid glandular differentiation: Report of a series with emphasis on the potential for misdiagnosis and discussion of the differential diagnosis. Histopathology 2009;54:365-73.  Back to cited text no. 3
[PUBMED]  [FULLTEXT]  
4.Bhargava R, Shia J, Hummer AJ, Thaler HT, Tornos C, Soslow RA. Distinction of endometrial stromal sarcomas from 'hemangiopericytomatous' tumors using a panel of immunohistochemical stains. Mod Pathol 2005;18:40-7.  Back to cited text no. 4
    
5.Nucci MR, Harburger D, Koontz J, Dal Cin P, Sklar J. Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am J Surg Pathol 2007;31:65-70.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  

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Correspondence Address:
Sushma Bhargava
"Geetanjali" 20/2 Old Palasia, Behind Anand Bazaar, Indore, Madhya Pradesh - 452 018
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.77419

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