LGCmain
Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 3488
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
IJPM is coming out with a Special issue on "Genitourinary & Gynecological pathology including Breast". Please submit your articles for these issues
ORIGINAL ARTICLE
Year : 2011  |  Volume : 54  |  Issue : 2  |  Page : 284-289

Expression of human mammaglobin and clinicopathologic correlations in breast cancer: The findings in Malaysia


1 Department of Biomedical Sciences, Faculty of Allied Health Sciences, National University of Malaysia (Universiti Kebangsaan Malaysia), Jalan Raja Muda Abdul-Aziz, Kuala Lumpur, Malaysia
2 Department of Chemical Pathology, School of Medical Sciences, University of Science of Malaysia (Universiti Sains Malaysia), Kota Bharu, Malaysia

Correspondence Address:
Fawwaz S Al-Joudi
Department of Biomedical Science, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul-Aziz, Kuala Lumpur 50300
Malaysia
Login to access the Email id

Source of Support: Universiti Kebangsaan Malaysia (National University of Malaysia (Research Grant No. 02-01-02-SF0122)., Conflict of Interest: None


DOI: 10.4103/0377-4929.81596

Rights and Permissions

Background: Human mammaglobin (hMAG) is a secreted protein which has been detected in breast epithelial cells of mammary glands and has been used as a specific marker for breast cancer. Objectives: This study aims at studying the hMAG expression and identifying the significant predictors of hMAG expression in breast cancer tissues. Materials and Methods: The tissue samples were obtained from two major teaching hospitals in the country. They were examined by immunohistochemistry (IHC) and the hMAG expression was evaluated using an established scoring system. Results: Out of 84 breast cancer tissue samples, hMAG was expressed in 50 samples (59.6%). The expression of hMAG was found to be increased with cancer grade. The output of logistic regression model showed that hMAG was overexpressed in breast cancer samples from the first hospital (P = 0.014), but not with those from the second hospital. Conclusions: It can be concluded that hMAG may serve in the diagnosis and the assessment of progression with the increased cancer grade. The dominance in hMAG expression in samples from HUSM may correlate with ethnic, environmental or genetic factors.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3049    
    Printed162    
    Emailed2    
    PDF Downloaded141    
    Comments [Add]    
    Cited by others 6    

Recommend this journal