Indian Journal of Pathology and Microbiology
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Year : 2011  |  Volume : 54  |  Issue : 2  |  Page : 284-289

Expression of human mammaglobin and clinicopathologic correlations in breast cancer: The findings in Malaysia

1 Department of Biomedical Sciences, Faculty of Allied Health Sciences, National University of Malaysia (Universiti Kebangsaan Malaysia), Jalan Raja Muda Abdul-Aziz, Kuala Lumpur, Malaysia
2 Department of Chemical Pathology, School of Medical Sciences, University of Science of Malaysia (Universiti Sains Malaysia), Kota Bharu, Malaysia

Correspondence Address:
Fawwaz S Al-Joudi
Department of Biomedical Science, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul-Aziz, Kuala Lumpur 50300
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Source of Support: Universiti Kebangsaan Malaysia (National University of Malaysia (Research Grant No. 02-01-02-SF0122)., Conflict of Interest: None

DOI: 10.4103/0377-4929.81596

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Background: Human mammaglobin (hMAG) is a secreted protein which has been detected in breast epithelial cells of mammary glands and has been used as a specific marker for breast cancer. Objectives: This study aims at studying the hMAG expression and identifying the significant predictors of hMAG expression in breast cancer tissues. Materials and Methods: The tissue samples were obtained from two major teaching hospitals in the country. They were examined by immunohistochemistry (IHC) and the hMAG expression was evaluated using an established scoring system. Results: Out of 84 breast cancer tissue samples, hMAG was expressed in 50 samples (59.6%). The expression of hMAG was found to be increased with cancer grade. The output of logistic regression model showed that hMAG was overexpressed in breast cancer samples from the first hospital (P = 0.014), but not with those from the second hospital. Conclusions: It can be concluded that hMAG may serve in the diagnosis and the assessment of progression with the increased cancer grade. The dominance in hMAG expression in samples from HUSM may correlate with ethnic, environmental or genetic factors.

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