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  Table of Contents    
LETTER TO EDITOR  
Year : 2011  |  Volume : 54  |  Issue : 2  |  Page : 434-435
Comment on: Synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland


Department of Pathology, Burdwan Medical College, Burdwan, West Bengal- 713 104, India

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Date of Web Publication27-May-2011
 

How to cite this article:
Wasim NA, Hati GC, Guha D, Bhattacharya S. Comment on: Synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland. Indian J Pathol Microbiol 2011;54:434-5

How to cite this URL:
Wasim NA, Hati GC, Guha D, Bhattacharya S. Comment on: Synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland. Indian J Pathol Microbiol [serial online] 2011 [cited 2019 Dec 16];54:434-5. Available from: http://www.ijpmonline.org/text.asp?2011/54/2/434/81625


Sir,

We have read with interest the case report entitled "Synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland" [1] and we would like to share our views. We also had a case of "Cystic papillary thyroid carcinoma with follicular adenoma." Neither in our case nor in the case reported by Ganguly et al[1] was there any evidence of nodular goiter or autoimmune thyroiditis, the conditions that have been implicated as predisposing factors of thyroid carcinoma. [2] On the contrary, in both of these cases there was a coexistent follicular adenoma, which is not known to undergo malignant transformation. It has been pointed by Ganguly et al[1] that ploidy analyses show aneuploidy in the differentiated components of thyroid cancers in addition to anaplastic component. However, it is also known that inactivating point mutation in p53 tumor suppressor genes are rare in well-differentiated thyroid carcinomas but common in anaplastic carcinoma of thyroid. [3] But the implication of coexistent follicular adenoma cannot be properly elucidated. A detailed and meticulous genetic study will probably throw light on this issue and also help to clarify the scenario.

 
   References Top

1.Ganguly R, Mitra S, Dutta AK. Synchronous occurrence of anaplastic, follicular and papillary carcinoma with follicular adenoma in thyroid gland. Indian J Pathol Microbiol 2010;53:337-9.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Gagel RF, Goepfert H, Callender DL. Changing concepts in the pathogenesis and management of Thyroid carcinoma. CA cancer J Clin 1996;46:261-83.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.Fagin JA, Matsuo K, Karmakar A, Chen DL, Tang SH, Koeffler HP. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinoma. J Clin Inv 1993;91:179-84.  Back to cited text no. 3
    

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Correspondence Address:
Debasish Guha
Department of Pathology, Burdwan Medical College, Burdwan, West Bengal- 713 104
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.81625

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