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Indian Journal of Pathology and Microbiology
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CASE REPORT
Year : 2012  |  Volume : 55  |  Issue : 4  |  Page : 528-530

Pigmented hepatocellular adenoma with complete CD34 immunostaining pattern: A diagnostic dilemma


1 Department of Pathology, Global Hospital and Health City, Chennai, Tamil Nadu, India
2 Department of Hepatobiliary Surgery and Liver Transplantation, Global Hospital and Health City, Chennai, Tamil Nadu, India

Correspondence Address:
Sushma Patra
Department of Pathology, Global Hospital and Health City, Chennai - 600 100, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.107801

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WHO defines hepatocellular adenoma (HCA) as a benign tumor composed of cells closely resembling normal hepatocytes, which are arranged in plates separated by sinusoids. It is more common in women. The present concerns a 41 years female who was found to have a mass lesion in liver on ultrasound while undergoing routine evaluation for dyspepsia. Computed tomography scan of abdomen showed 10 × 8 cm lesion in liver. Extended left hepatectomy was performed. Grossly hepatic cut surface showed circumscribed tumor with dark gray or black color. Microscopy revealed hepatocellular adenoma with abundant Dubin Johnson like pigment deposition. CD34 immunostaining showed complete sinusoidal pattern. We labeled the tumor as pigmented hepatic adenoma with complete CD34 staining pattern. To the best of author's knowledge only eight cases of pigmented hepatocellular adenoma are described in world literature.


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