Indian Journal of Pathology and Microbiology
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Year : 2013  |  Volume : 56  |  Issue : 3  |  Page : 291-293

Hepatic metastasis with heterologous rhabdomyoblastic differentiation in a patient with gastrointestinal stromal tumor treated with imatinib

1 Department of Pathology, Global Hospital and Health City, Chennai, Tamil Nadu, India
2 Liver Transplantation and Heptobiliary Surgery, Global Hospital and Health City, Chennai, Tamil Nadu, India

Correspondence Address:
Mukul Vij
Department of Pathology, Global Health City, Chennai, Tamil Nadu - 600 100
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.120402

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the intestinal tract. In patients with locally advanced and/or metastatic GIST, the introduction of tyrosine kinase inhibitor, imatinib mesylate, has transformed the management of this previously untreatable neoplasm into a treatable entity. Approximately 80% of advanced metastatic GISTs respond to imatinib treatment. However, the majority of patients suffer disease progression at a median of 2 years due to drug resistance. Generally progressing GISTs retain their typical morphology. Herein, we report an extremely rare case of progressive metastatic GIST with heterologous rhabdomyoblastic differentiation after, imatinib mesylate treatment. We also review the relevant literature.

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