LGCmain
Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 3103
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
CASE REPORT
Year : 2013  |  Volume : 56  |  Issue : 4  |  Page : 428-433

Novel molecular aberrations and pathologic findings in a tubulocystic variant of renal cell carcinoma


1 Department of Pathology; ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
2 ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
3 Division of Cytogenetics, Cleveland Clinic Foundation, Cleveland, OH, USA
4 Department of Pediatrics and Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, UT, USA
5 Department of Urology, University of Utah Health Sciences Center, Salt Lake City, UT, USA
6 Department of Medical Oncology, University of Utah Health Sciences Center, Salt Lake City, UT, USA

Correspondence Address:
Ting Liu
Department of Pathology, Huntsman Cancer Hospital, Level 6 and University of Utah Health Sciences Center, Salt Lake City, UT 84132
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.125361

Rights and Permissions

Tubulocystic renal cell carcinoma (TRCC) is an indolent type of renal cell carcinoma with a good prognosis based on the limited number of published cases. Herein, we describe the unusual clinical, pathologic and molecular findings in a case of TRCC. Our patient with TRCC had two local recurrences and a brain metastasis following radical nephrectomy. Unusual histologic findings included focal solid growth pattern and cytologic atypia. A genome-wide molecular inversion probe assay identified copy number (CN) loss in three chromosome regions and one region with copy-neutral loss of heterozygosity (copy-neutral LOH). Copy number variations (CNVs) were observed (chromosomes 4p16.1 and 17q21.31-q21.32) in both the tumor and the normal tissue, and most likely represents benign variations. The loss of entire chromosomes 9, 18 and 15 and copy-neutral LOH involving 6p22.1 was observed only in the tumor. The presence of these clinical, pathologic and molecular findings could be related to an increased risk for tumor recurrence and poor prognosis. The novel molecular findings described in TRCC might represent new targets for novel therapies.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2144    
    Printed55    
    Emailed1    
    PDF Downloaded73    
    Comments [Add]    
    Cited by others 2    

Recommend this journal