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Year : 2013  |  Volume : 56  |  Issue : 4  |  Page : 470
Extensively calcified cystic extraventricular neurocytoma


1 Department of Pathology, Govt. Medical College, Kozhikode, Kerala, India
2 Department of Neurosurgery, Govt. Medical College, Kozhikode, Kerala, India

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Date of Web Publication18-Jan-2014
 

How to cite this article:
Govindan A, Peettakkandy V, Alapatt JP. Extensively calcified cystic extraventricular neurocytoma. Indian J Pathol Microbiol 2013;56:470

How to cite this URL:
Govindan A, Peettakkandy V, Alapatt JP. Extensively calcified cystic extraventricular neurocytoma. Indian J Pathol Microbiol [serial online] 2013 [cited 2019 Dec 12];56:470. Available from: http://www.ijpmonline.org/text.asp?2013/56/4/470/125381


A 29-years-old female presented with complaints of occipital headache and blurring of vision of 6 months duration. Cranial MR Imaging showed an intra-axial, cystic lesion in the right parieto-occipital region, with a T1 isointense [Figure 1]a) and T2 hypointense [Figure 1]b) focally enhancing mural nodule on T1W contrast image (A: inset), without any communication to the lateral ventricle. Per-operatively, the cyst contained clear yellowish fluid and a calcified, friable, relatively avascular nodule in its depth. Histopathological examination showed a hypocellular tumor with extensive calcification [Figure 1]c: H&E × 40, Figure 1d: H&E × 100). The tumor cells were uniform with round to oval nuclei having fine speckled chromatin and interspersed fibrillary areas [Figure 1]f: H&E × 400). The tumor cells were immunopositive for the neuronal marker, synaptophysin [Figure 1]e × 100, [Figure 1] Finset × 400).
Figure 1: Axial MR image shows cysti c extraventricular tumour with a T1 isointense and T2 hypointense mural nodule (a, b) with contrast enhancement in the mural nodule and part of cyst wall (a, inset). The mural nodule shows diff usion restricti on and calcifi cati on (b, inset). The ypocellular to cellular tumor (d: H&E ×100) exhibits extensive calcifi cati on (c: H&E ×40). The umor cells have round nucleus speckled chromati n and clear cytoplasm (f: H&E ×400) and are ositi ve for synaptophysin (e: ×100, f inset ×400).

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Extraventricular neurocytomas are rare neurocytic neoplasms located outside the ventricular system with histological features similar to central neurocytomas. Giangaspero et al in 1997 first described extraventricular neurocytic neoplasms in a report of 11 cases. [1],[2] They were first included as a separate entity in the 2007 WHO classification of tumors of the central nervous system as a variant of central neurocytoma. They are known to show a cyst-mural nodule configuration, lower cellularity, and ganglionic differentiation, more commonly than their intraventricular counterparts. A close histopathological differential diagnosis is oligodendroglioma. Neuronal nature of these tumors is confirmed immunohistochemically by positivity for synaptophysin. In the present case, the circumscription of the tumor, cystic nature with a mural nodule, and positivity for synaptophysin, differentiated it from oligodendroglioma.[3].

 
   References Top

1.Brat DJ, Scheithauer BW, Eberhart CG, Burger PC: Extraventricular Neurocytomas: Pathologic features and clinical outcome. Am J Surg Pathol 2001;25:1252-60.  Back to cited text no. 1
    
2.Choi H, Park SH, Kim DG, Paek SH. Atypical extraventricular neurocytoma. J Korean Neurosurg Soc 2011;50:381-4.  Back to cited text no. 2
    
3.Figarella-Branger D, Söylemezoglu F, Burger PC. Central neurocytoma and extraventricular neurocytoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, (editors) WHO classification of tumors of the Central Nervous System. 4th ed. Lyon: International Agency for Research on Cancer;2007 pp 106-9.  Back to cited text no. 3
    

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Correspondence Address:
Aparna Govindan
Department of Pathology, Govt. Medical College, Kozhikode - 673 008, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.125381

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This article has been cited by
1 Clinical Manifestations of Central Neurocytoma
Isaac Yang,Nolan Ung,Lawrance K. Chung,Daniel T. Nagasawa,Kimberly Thill,Junmook Park,Stephen Tenn
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[Pubmed] | [DOI]



 

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