Indian Journal of Pathology and Microbiology
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Year : 2014  |  Volume : 57  |  Issue : 3  |  Page : 431-434

Loss of chromosome Y in acute lymphoblastic leukemia: Age related or neoplastic phenomenon?

1 Department of Cytogenetics, Tata Medical Center, Kolkata, India
2 Department of Laboratory Hematology, Tata Medical Center, Kolkata, India

Correspondence Address:
Mayur Parihar
Department of Cytogenetics, Tata Medical Center, Kolkata - 700 156
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.138742

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Loss of chromosome Y (LOY) in the bone marrow has long been considered as an age-related phenomenon with an incidence of more than 25% in males beyond the age of 80 years. Though reported as an acquired abnormality in myeloid neoplasms, it has rarely been described in B-lymphoblastic leukemia which primarily is a disease of the young. We describe here in three cases of pediatric B-lymphoblastic leukemia with LOY. Conventional cytogenetic studies and fluorescence in situ hybridization studies using centromeric probes for chromosome X and Y on peripheral blood samples ruled out constitutional LOY in all the three cases favoring it to be a neoplastic phenomenon.

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