LGCmain
Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 4544
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
IJPM is coming out with a Special issue on "Genitourinary & Gynecological pathology including Breast". Please submit your articles for these issues


 
  Table of Contents    
QUIZ PAGE  
Year : 2014  |  Volume : 57  |  Issue : 4  |  Page : 642
Quiz 6/ 2014


Professor of PathologyGovt Medical College Kozhikode, Kerala, India

Click here for correspondence address and email

Date of Web Publication11-Oct-2014
 

How to cite this article:
Aravindan K P. Quiz 6/ 2014. Indian J Pathol Microbiol 2014;57:642

How to cite this URL:
Aravindan K P. Quiz 6/ 2014. Indian J Pathol Microbiol [serial online] 2014 [cited 2019 Dec 13];57:642. Available from: http://www.ijpmonline.org/text.asp?2014/57/4/642/142724


Direct immunofluorescence of a skin biopsy (Anti IgG).



Pemphigus erythematosus: The picture shows the classic fish-net appearance due to the deposition of anti-IgG antibody around the epidermal cells. But, in addition, there is also a granular deposit all along the basement membrane zone.[1],[2] This combination is characteristic of a variant of pemphigus foliaceus named pemphigus eryhtematosus. It is characterized by subcorneal blistering and intraepidermal deposition of IgG antibodies that bind the desmosomal cadherin desmoglein 1 (Dsg1). It was was first described in 1926 by Senear and Usher as a condition with a lupus like butterfly rash, which they suggested was a combination of pemphigus vulgaris and lupus erythematosus (LE). [3]

Paraneoplastic pemphigus is another lesion which on occasion can have this combination of epidermal and basement membrane zone deposition of IgG. Antibodies against plakin proteins are present in the serum and there is an underlying lymphoproliferative disorder in most of these cases.



 
   References Top

1.
Chorzelski T, Jabloñska S, Blaszczyk M. Immunopathological investigations in the Senear-Usher syndrome (coexistence of pemphigus and lupus erythematosus). Br J Dermatol. 1968;80:211-7.   Back to cited text no. 1
    
2.
Amerian ML, Ahmed AR. Pemphigus erythematosus. Senear-Usher syndrome. Int J Dermatol. 1985;24:16-25.  Back to cited text no. 2
    
3.
Oktarina DA, Poot AM, Kramer D, Diercks GF, Jonkman MF, Pas HH. The IgG "lupus-band" deposition pattern of pemphigus erythematosus: Association with the desmoglein 1 ectodomain as revealed by 3 cases. Arch Dermatol. 2012;148:1173-8.  Back to cited text no. 3
    

Top
Correspondence Address:
K P Aravindan
Professor of PathologyGovt Medical College Kozhikode, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions




 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


    References

 Article Access Statistics
    Viewed797    
    Printed18    
    Emailed0    
    PDF Downloaded80    
    Comments [Add]    

Recommend this journal