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CLINICO PATHOLOGICAL CONFERENCE
Year : 2015  |  Volume : 58  |  Issue : 1  |  Page : 48-54

A young leukemic patient with unusual catastrophic intestinal complication


1 Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
2 Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
3 Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
4 Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India

Correspondence Address:
Kim Vaiphei
Department of Histopathology, Room No 505, 5th Floor, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012
India
Pankaj Malhotra
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.151187

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A 14-year-old child with acute lymphoblastic leukemia who had completed induction chemotherapy presented with fever and diffuse musculoskeletal pains which was thought to be a constellation of myositis, arthralgias and arthritis. Investigations revealed initially showed normal peripheral blood counts but had pancytopenia and pre-terminally blasts were seen in the peripheral blood smear. He had bone marrow necrosis. Disseminated intravascular coagulation was suspected with a positive fungal serology. At autopsy, he had evidence of disease relapsed in lymph nodes, liver, spleen, testes and kidneys. There was extensive pseudomembranous colitis and appendicitis with changes of toxic megacolon.


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