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LETTER TO EDITOR  
Year : 2015  |  Volume : 58  |  Issue : 2  |  Page : 265
Mycobacterium tuberculosis antigen expression in cerebrospinal fluid monocytes


1 Medical Science, Medical Center, Shantou, China
2 Tropical Medicine, Hainan Medical University, China

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Date of Web Publication17-Apr-2015
 

How to cite this article:
Tin SS, Wiwanitkit V. Mycobacterium tuberculosis antigen expression in cerebrospinal fluid monocytes. Indian J Pathol Microbiol 2015;58:265

How to cite this URL:
Tin SS, Wiwanitkit V. Mycobacterium tuberculosis antigen expression in cerebrospinal fluid monocytes. Indian J Pathol Microbiol [serial online] 2015 [cited 2020 Feb 20];58:265. Available from: http://www.ijpmonline.org/text.asp?2015/58/2/265/155365


Editor,

We would like to discuss on the publication on Mycobacterium tuberculosis antigen expression in cerebrospinal fluid (CSF) monocytes. [1] Song et al. concluded that "the positive expression of ESAT-6 in CSF monocytes is helpful for the early diagnosis of TBM. [1]" The proposed technique might possible for diagnosis of TBM. However, the problem is whether it can provide early diagnosis and cost effective. Based on the given information by Song et al., there is no information on required turnaround time and cost of test. Hence, it is not possible to mention that the test can provide early diagnosis. Furthermore, the cost-effectiveness is the big issue to be discussed. In addition, the sensitivity, specificity and accuracy of the test require system evaluation. Without comparative study to other available tests, the conclusion cannot be set. Other new alternative tools such as PCR diagnosis might be more accurate and give faster result. [2] As concluded by Panagariya et al., "the CSF PCR estimation in clinically suspected cases of tuberculous meningitis may be an extremely valuable test for early diagnosis and institution of specific therapy. [3]

 
   References Top

1.
Song FX, Sun XW, Wang XT, Nai Y, Liu ZL. Significance of Mycobacterium tuberculosis antigen expression in cerebrospinal fluid monocytes in diagnosing tuberculous meningitis. Indian J Pathol Microbiol 2014;57:265-8.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Dayal R, Kashyap H, Pounikar G, Kamal R, Yadav NK, Singh MK, et al. Real time PCR in childhood tuberculosis: A valuable diagnostic tool. Indian J Pediatr 2015;82:189-91.  Back to cited text no. 2
    
3.
Panagariya A, Sureka RK, Ralot T, Sharma B, Dubey P. Clinicodiagnostic features of tuberculous meningitis and the role of CSF PCR in early diagnosis: A study from north-west India. J Indian Med Assoc 2013;111:309-12, 314.  Back to cited text no. 3
    

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Correspondence Address:
Prof. Sim Sai Tin
Medical Center, Shantou
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.155365

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