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  Table of Contents    
EDITORIAL  
Year : 2015  |  Volume : 58  |  Issue : 3  |  Page : 273
From Editor's desk


Department of Pathology, MLN Medical College, Allahabad, Uttar Pradesh, India

Click here for correspondence address and email

Date of Web Publication14-Aug-2015
 

How to cite this article:
Misra V. From Editor's desk. Indian J Pathol Microbiol 2015;58:273

How to cite this URL:
Misra V. From Editor's desk. Indian J Pathol Microbiol [serial online] 2015 [cited 2020 Jun 5];58:273. Available from: http://www.ijpmonline.org/text.asp?2015/58/3/273/162829


We all know that the field of pathology is rapidly moving from morphology to molecular diagnosis. In the present era of targeted therapy, it has become imperative to study the changes at genetic and molecular level to identify the specific targets for selected therapy. Matrix metalloproteinases (MMP) are enzymes that degrade extracellular matrix proteins and facilitate cancer invasion and metastasis. Different MMPs have been studied in a variety of cancers. MMP-7 (matrilysin 1) is a 28 kDa protein that cleaves collagen types IV and X, elastin, fibronectin, gelatin, laminin, and proteoglycans. It is regulated mainly by tissue inhibitor of metalloproteinases-1 (TIMP-1) and TIMP-2.[1] MMPs have been studied in serum, as well as in tissues. It has been shown that increased expression of certain MMPs correlates with poor prognostic parameters.

MMP-7 is expressed in tumor epithelial cells rather than stromal cells in contrast to other MMPs and has a role in many stages of tumor progression, including tumor formation, growth, invasion, metastasis, and inflammation.

Marimastat, a general MMP inhibitor has been studied under phase III trial and showed an improved response on the survival of the patient with pancreatic adenocarcinomas. MMP-7 has been studied largely in pancreatic head cancer within the periampullary group. There is not enough information on the expression of MMP-7 in other tumors of the periampullary group. In Indian population, the ampullary carcinoma forms the bulk (approximately 85%) of all resected pancreaticoduodenectomies. Neeraj Kumari et al. [1] studied MMP-7 expression and its correlation with clinicopathological variables in ampullary cancer and its histological subtypes (intestinal and pancreatobiliary) and found MMP-7 expression in nearly 64 % of ampullary cancer and showed a significant correlation with low pathological (T-) stage and high overall stage with a shorter survival, leading to an option of exploration of MMP inhibitor therapy in the future for periampullary carcinoma.

In every field of pathology researchers and scientists are working hard to develop better parameters and indices that may help the clinicians in correct diagnosis and better differentiation of diseases having similar morphology, but different pathogenesis and treatment. The screening tool should not only be sensitive but also specific so as to be cost-effective and save the time of the patient, as well as the treating physician. For example, beta thalassemia trait (BTT) must be differentiated from iron deficiency anemia to avoid unnecessary iron therapy and for the prevention of thalassemia major by genetic counseling. The article by Sehgal et al.[2] in this issue highlights the evaluation of new Sehgal index and compares it to existing complete blood count-based indices for the best combination of sensitivity and specificity to predict BTT.

Outbreaks of dengue infection occur in several parts of India with clockwork precision closely related to changing seasons and leading to severe morbidity. Palanivel et al.[3] did a prospective. Study to characterize the demographic, diagnostic, and clinical profile of pediatric patients in a tertiary care center. The combination of clinical findings and rapid NS1, IgM detection, helped in confirming the diagnosis for appropriate management of dengue in children.

In last few issues, we have added new columns such as a quiz, clinicopathological conference, book reviews, and a tribute to our senior members. All the authors and senior members are requested to contribute to these columns. The pattern of writing can be according to instructions and published articles in the journal.

In the end, I cannot forget to remind you about the issues of ethics, plagiarism and following the instructions of the journal while preparing a manuscript.

With best wishes

 
   References Top

1.
Kumari N., Singh R. K., Krishnani N., Shukla R. Matrix metalloproteinase 7 expression in ampullary carcinoma. Indian J Pathol Microbiol 2015;58:274-8.   Back to cited text no. 1
    
2.
Sehgal K., Mansukhani V., Dadu T., Irani M., Khodaiji S. Sehgal index: A new index and its comparison with other complete blood count-based indices for screening of beta thalassemia trait in a tertiary care hospital. Indian J Pathol Microbiol 2015;58:310-5.  Back to cited text no. 2
    
3.
Palanivel H., Nair S., Subramaniyan A., Ratnam P.V.J., Kanungo R. Dengue virus infection: Need for appropriate laboratory tests for diagnosis and management of the condition in children during an outbreak. Indian J Pathol Microbiol 2015;58:328-31.  Back to cited text no. 3
    

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Correspondence Address:
Vatsala Misra
Department of Pathology, MLN Medical College, Allahabad, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.162829

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