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CASE REPORT
Year : 2015  |  Volume : 58  |  Issue : 4  |  Page : 546-549

Primary Burkitt's lymphoma of the breast without Epstein-Barr virus infection: A case report and literature review


1 Department of Pathology, Shaoxing People's Hospital, Shaoxing, People’s Republic of China
2 Department of Oncology, The People's Hospital of Jiangshan, Jiangshan, Zhejiang, People’s Republic of China
3 Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, People’s Republic of China
4 Department of Ultrasound, The General Military Hospital of Beijing PLA, Beijing 100700, People’s Republic of China

Correspondence Address:
Dr. Chunwei Xu
Department of Pathology, The General Military Hospital of Beijing PLA, Nanmen Warehouse 5, Dongsishitiao Street, Dongcheng, Beijing 100700
People’s Republic of China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.168863

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Burkitt lymphoma (BL) is a highly aggressive neoplasm, which arising from the germinal center or post germinal center B-cell. Primary breast lymphomas are extremely rare, and the most common histologic type is diffuse large B-cell lymphoma. Primary BL of the breast is much less common than the other types of lymphoma. Here, we report an extremely rare case of a 37-year-old Chinese female with localized bilateral breast, who was referred to our institution for bilateral breast swelling. The left breast tissue ultrasonography showed the short axis measuring 20.3 mm × 18.8 mm and the long axis measuring 22.1 mm × 20.8 mm soft tissue mass. The right breast tissue ultrasonography showed the short axis measuring 30.2 mm × 26.9 mm and the long axis measuring 33.5 mm × 2.18 mm. Coarse needle biopsy of breast masses demonstrated a non-Hodgkin's B-cell lymphoma. The patient underwent a bilateral mastectomy. Histological examination of the tumor showed a characteristic "starry sky" pattern, the medium-sized tumor cells were a monotonous pattern of growth, and there were many abnormal mitotic figures. The neoplastic cells strongly expressed CD20, CD79-μ, MUM-1, PAX-5, CD43 and Bcl-6, Ki-67 were nearly 100% positive, but negative for CD10, Bcl-2 and TdT. By fluorescence in situ hybridization an IGH-MYC gene fusion was detected in the tumor tissue which indicating the presence of a typical BL translocation t(8;14)(q24;q32). The final histopathological diagnosis was primary BL of the breast.


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