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CASE REPORT
Year : 2016  |  Volume : 59  |  Issue : 1  |  Page : 104-106

Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity


1 Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Transfusion Medicine and Immunohematology, Christian Medical College, Vellore, Tamil Nadu, India
3 Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
4 Department of Cytogenetics, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Mary P Chacko
Department of Transfusion Medicine and Immunohematology, Christian Medical College, Vellore, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.174829

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Acute myeloid leukemia (AML) is a malignant hematopoietic stem cell disorder which is sub-classified based on bone marrow morphology and the presence of specific genetic abnormalities. One such cytogenetic abnormality is the pericentric inversion (inv) of chromosome 16 which is typically seen in AML M4 with eosinophilia and is associated with a favorable prognosis. We report the inv (16) in a young woman with AML M5 and abnormal eosinophils. This is a rare entity with only about 20 cases being reported till date.


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