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CASE REPORT
Year : 2016  |  Volume : 59  |  Issue : 3  |  Page : 407-409

'Childhood systemic mastocytosis associated with t (8; 21) (q22; q22) acute myeloid leukemia'


1 Department of Pathology, Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India
2 Department of Cancer Cytogenetics, Tata Memorial Hospital, Mumbai, Maharashtra, India
3 Department of Pediatric Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Sumeet Gujral
727, Annexe Building, Tata Memorial Hospital, Dr. E Borges Road, Parel (East), Mumbai - 400 012, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.188140

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Systemic mastocytosis (SM) with associated clonal nonmast cell lineage disease is seen in up to 20% cases of SM. SM is uncommon in the pediatric population. T (8; 21) (q22; q22) is a good prognostic factor in acute myeloid leukemia (AML). However, the presence of SM confers poor prognosis in t (8; 21) (q22; q22) associated AML. We report the case of a child with t (8; 21) (q22; q22) associated AML with SM and her minimal residual disease status over the course of her treatment. In our case, the abnormal mast cells, showing co-expression of CD25 and CD2, persisted even after the marrow showed no evidence of residual AML.


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