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CASE REPORT
Year : 2016  |  Volume : 59  |  Issue : 4  |  Page : 545-547

Acute myeloid leukemia with t(4;12)(q12;p13): A morphological dilemma


1 Department of Cytogenetics, Tata Medical Center, Kolkata, West Bengal, India
2 Department of Laboratory Medicine, Tata Medical Center, Kolkata, West Bengal, India

Correspondence Address:
Mayur Parihar
Department of Cytogenetics, Tata Medical Center, Rajarhat, New Town, Kolkata - 700 156, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.191814

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Cytogenetics has a pivotal role in risk stratification of acute myeloid leukemia (AML). We report a case of AML with a t(4;12)(q12;p13). To the best of our knowledge, there are about 24 cases of t(4;12) reported in AML which are usually misdiagnosed as lymphoproliferative disorders on morphological assessment. This case showed specific clinical, morphological, and immunophenotypic features such as (1) pseudo lymphoid morphology, (2) dysplasia in granulocytic series, (3) an immature immunophenotype with positivity for CD34 and CD117, and (4) poor treatment response.


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