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  Table of Contents    
LETTER TO EDITOR  
Year : 2017  |  Volume : 60  |  Issue : 3  |  Page : 451-452
Helicobacter pylori prevalence and relation with obesity


1 3rd Grade Students of Marmara University, Faculty of Medicine, Istanbul, Turkey
2 Department of Medical Microbiology, Marmara University, Faculty of Medicine, Istanbul, Turkey
3 Department of Physiology, Marmara University, Faculty of Medicine, Istanbul, Turkey

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Date of Web Publication22-Sep-2017
 

How to cite this article:
Ozdemir SH, Aksu &, Ozden E, Narman I, Varlik S, Aksu B, Kasimay O, Yagci AK. Helicobacter pylori prevalence and relation with obesity. Indian J Pathol Microbiol 2017;60:451-2

How to cite this URL:
Ozdemir SH, Aksu &, Ozden E, Narman I, Varlik S, Aksu B, Kasimay O, Yagci AK. Helicobacter pylori prevalence and relation with obesity. Indian J Pathol Microbiol [serial online] 2017 [cited 2019 Dec 15];60:451-2. Available from: http://www.ijpmonline.org/text.asp?2017/60/3/451/215377


Editor,

We have read with great interest recently published paper of Saha et al., “Application of a stool antigen test to evaluate the burden of Helicobacter pylori infection in dyspepsia patients.”[1] They recommend initial testing for H. pylori stool antigen in dyspeptic patients before initiating treatment and before carrying out any invasive procedure such as endoscopy.

We also tested stool samples in Turkish patients to find out if H. pylori positivity is a risk factor for obesity. Recent studies about the relationship between H. pylori and insulin resistance and obesity has conflicting results such as some of them state that H. pylori prevalence is high in obese people; others state that H. pylori eradication increases obesity.

The prevalence of H. pylori changes to 44%–70% in Turkey where 30.4% of population is obese.[2],[3] People admitted to obesity clinic in Marmara University Hospital, Istanbul, were included in this study. Volunteers were informed, and their verbal and written consents were obtained. Participants with body mass index (BMI) ≥30 (n: 53), classified as obese, forming the test group and with BMI <30 (n: 52) classified as normal, forming the control group. They were asked for a stool sample and to fill out a survey including multiple-choice questions about gastrointestinal symptoms, underlying diseases, and current treatment.

Stool samples were tested for the presence of H. pylori by using two different rapid antigen tests (CerTest, Biotec, Italy and SD test, Standard Diagnostics, Korea) and an ELISA test (Generic Assays, Germany).

Definitive values were used for statistical evaluations of survey and antigen test results, whereas Chi-square test was used for comparative analysis.

Through 105 participants, 70 (66.7%) were female and 69 (62.7%) were over 18 years of age. Participants complaining about dyspepsia were 62.7% (n: 34) of obese group and 37.3% (n: 20) of control group. Among the complaints, heartburn, esophageal burning sensation, and constipation symptoms are significantly higher in the obese group.

According to ELISA test results, sensitivity and specificity were 56.5% and 96.7% for SD test and 91.3% and 93.3% for CerTest, respectively. Antigen positivity for obese group found as 45.3% (n: 24) and 38.5% (n: 20) for control group (P = 0.555). There was no significant relation between antigen positivity and having gastrointestinal complaints (for each symptom P > 0.05).

Lender et al.[4] have showed the inverse relation of obesity and H. pylori infection while Thjodleifsson et al.[5] have claimed a significant correlation between them. In a study from Turkey, H. pylori prevalence was 57.2% in obese and 27.0% in control group (P < 0.001) suggested that obesity could be a risk factor for H. pylori infection whereas we could not confirm this result in our study.[6]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Saha R, Roy P, Das S, Kaur N, Kumari A, Kaur IR, et al. Application of a stool antigen test to evaluate the burden of Helicobacter pylori infection in dyspepsia patients. Indian J Pathol Microbiol 2016;59:66-8.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Işıktaş Sayılar E, Çelik B, Dumlu Ş. Relationship between Helicobacter pylori infection and metabolic syndrome. Turk J Gastroenterol 2015;26:468-73.  Back to cited text no. 2
    
3.
Oğuz A, Temizhan A, Abaci A, Kozan O, Erol C, Ongen Z, et al. Obesity and abdominal obesity; an alarming challenge for cardio-metabolic risk in Turkish adults. Anadolu Kardiyol Derg 2008;8:401-6.  Back to cited text no. 3
    
4.
Lender N, Talley NJ, Enck P, Haag S, Zipfel S, Morrison M, et al. Review article: Associations between Helicobacter pylori and obesity – An ecological study. Aliment Pharmacol Ther 2014;40:24-31.  Back to cited text no. 4
    
5.
Thjodleifsson B, Olafsson I, Gislason D, Gislason T, Jögi R, Janson C, et al. Infections and obesity: A multinational epidemiological study. Scand J Infect Dis 2008;40:381-6.  Back to cited text no. 5
    
6.
Arslan E, Atilgan H, Yavaşoğlu I. The prevalence of Helicobacter pylori in obese subjects. Eur J Intern Med 2009;20:695-7.  Back to cited text no. 6
    

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Correspondence Address:
Aysegul Karahasan Yagci
Department of Medical Microbiology, Faculty of Medicine, Marmara University, Istanbul
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJPM.IJPM_374_16

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