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Year : 2019  |  Volume : 62  |  Issue : 4  |  Page : 586-588

Primary epiglottic follicular variant of peripheral T-cell lymphoma


1 Department of Pathology, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian 116011, Liaoning, China
2 Department of Pathology, Yanbian University Medical College, 977 Gongyuan Road, Yanji 133002, Jilin, China

Correspondence Address:
Lizhi Zhang
Department of Pathology, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian - 116011, Liaoning
China
Zhenhua Lin
Department of Pathology, Yanbian University Medical College, 977 Gongyuan Road, Yanji 133002, Jilin
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJPM.IJPM_849_18

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The follicular variant of peripheral T-cell lymphoma, not otherwise specified, is very rare. Primary epiglottic follicular variant of peripheral T-cell lymphoma is extremely rare in clinical practice. Here, we report the first case of a follicular variant of peripheral T-cell lymphoma not otherwise specified in a 44-year-old Chinese man, who presented with a tumor in the middle of the epiglottis tongue surface. Microscopically, the tumor had a vague nodular growth pattern and the morphology of the nodules was different from each other at low power. Atypical lymphoid cells were medium to large in size and had round nuclei, with an irregular nuclear membrane, distinct nucleoli, and rapid mitotic activity. Plasma cells were found surrounding the nodules. The tumor cells were positive for follicular helper T-cell markers (CD10, PD-1, CXCL13, and BCL-6). The EBER was negative by in situ hybridization. Polymerase chain reaction-based analysis showed monoclonal rearrangements of TCRβ, TCRγ, and polyclonal rearrangements of IgH, IgK, and IgL. The clinical and imaging features and the prognostic factors of FV PTCL-NOS remain poorly understood. Thus, investigation of more cases and longer follow-up is necessary to understand the disease and to identify the best treatment to improve prognosis.


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