Indian Journal of Pathology and Microbiology
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Year : 2020  |  Volume : 63  |  Issue : 1  |  Page : 44-48

Chorioamnionitis: Establishing a correlation between clinical and histological diagnosis

Department of Pathology, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia

Correspondence Address:
Khaldoon Aljerian
Department of Pathology, College of Medicine, King Saud University, Riyadh 12372
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_464_19

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Introduction: Chorioamnionitis that is associated with high rates of morbidity and mortality needs an early diagnosis for effective treatment. However, views are conflicting on the effectiveness of a clinical versus a histological diagnosis of the disease. The accuracy of clinical diagnoses should be evaluated by determining their correlation with histopathological data. Methods: A total of 696 placental records from single and multiple pregnancies between January 2011 and February 2018 were collected and reviewed to determine if chorioamnionitis was present. Results: Of the 696 records, 255 had histological data available, and of these, histological evidence for chorioamnionitis was recorded in 135 (52.9%). Clinical chorioamnionitis diagnosis was insensitive (26.7%; 95% confidence interval 19.43%–34.96%) and inaccurate (61.1%; 95% confidence interval 54.90%–67.19%). As well, 73.3% of histologically positive chorioamnionitis cases were missed using clinical indicators. Discussion: Clinical diagnosis for chorioamnionitis is inaccurate; in our study, most of the positive cases were not diagnosed using clinical indicators. However, of the clinical indicators examined, maternal and fetal tachycardia were the most reliable.

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