Indian Journal of Pathology and Microbiology


Year
: 1995  |  Volume : 38  |  Issue : 3  |  Page : 267--71

Bone marrow involvement in Hodgkin«SQ»s disease -- clinicopathological study of seven cases.


R Chopra, S Kumar, R Rana, A Zachariah 
 Departments of Pathology and Medicine, Christian Medical College, Ludhiana

Correspondence Address:
R Chopra
Departments of Pathology and Medicine, Christian Medical College, Ludhiana

Bone marrow involvement was observed in 7 cases amongst a total of 75 cases of Hodgkin«SQ»s disease encountered between January 1981 and June 1990; thus representing an incidence of 9.3 percent. Analysis of these 7 cases showed male preponderance. The age ranged from 26 to 74 years. All patients presented within seven months of onset of symptoms; and all had symptoms at presentation. Lymphadenopathy was found in all the cases, splenomegaly was present in six; and hepatomegaly in 4 cases. Mixed cellularity and lymphocytic depletion subtypes showed the highest frequency of marrow involvement (6 cases; 85.7 percent). Alkaline phosphatase was raised in 6 cases (85.7%). All cases received standard combination chemotherapy with or without local radiation therapy. Two years follow-up revealed an overall survival of 42.9%. Replace free survival at the end of two years was zero, as all the cases relapsed within seven months of initiation of treatment.


How to cite this article:
Chopra R, Kumar S, Rana R, Zachariah A. Bone marrow involvement in Hodgkin's disease -- clinicopathological study of seven cases. Indian J Pathol Microbiol 1995;38:267-71


How to cite this URL:
Chopra R, Kumar S, Rana R, Zachariah A. Bone marrow involvement in Hodgkin's disease -- clinicopathological study of seven cases. Indian J Pathol Microbiol [serial online] 1995 [cited 2020 May 24 ];38:267-71
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=1995;volume=38;issue=3;spage=267;epage=71;aulast=Chopra;type=0