Indian Journal of Pathology and Microbiology


Year
: 1995  |  Volume : 38  |  Issue : 3  |  Page : 287--92

Effect of anti-tuberculosis drugs on the iron-sequestration mechanisms of mycobacteria.


B Raghu, G R Sarma, P Venkatesan 
 Department of Biochemistry, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Madras

Correspondence Address:
B Raghu
Department of Biochemistry, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Madras

The effect of sub-lethal concentrations of isoniazid, ethambutol, rifampicin and pyrazinamide on the growth in vitro and the production of both exochelins and mycobactins by the high virulent and the South Indian low virulent strains of M. tuberculosis was examined under iron-deficient and iron-rich conditions. There was a marked decrease in the growth of both strains in the presence of increasing concentrations of all four drugs, the inhibition being total in the presence of minimal inhibitory concentrations of the drugs. It was also observed that the growth-inhibitory effect of all four drugs was slightly reversed in the presence of high concentration of iron in the medium. A significant increase was observed in the concentrations of both siderophores in the presence of all four drugs, under both iron-deficient (or) iron-rich conditions.


How to cite this article:
Raghu B, Sarma G, Venkatesan P. Effect of anti-tuberculosis drugs on the iron-sequestration mechanisms of mycobacteria. Indian J Pathol Microbiol 1995;38:287-92


How to cite this URL:
Raghu B, Sarma G, Venkatesan P. Effect of anti-tuberculosis drugs on the iron-sequestration mechanisms of mycobacteria. Indian J Pathol Microbiol [serial online] 1995 [cited 2020 May 29 ];38:287-92
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=1995;volume=38;issue=3;spage=287;epage=92;aulast=Raghu;type=0