Indian Journal of Pathology and Microbiology


Year
: 1997  |  Volume : 40  |  Issue : 1  |  Page : 3--10

Correlation of the growth fraction, nucleolar organizer region counts and epidermal growth factor receptor with histomorphological prognostic criteria in breast cancer.


G R Gupta, B N Datta, S M Bose, K Joshi 
 Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
G R Gupta
Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

A total of 60 cases of breast cancer were studied to find the correlation between newer parameters of prognosis viz growth fraction (GF), nucleolar organizer region (AgNOR) counts and epidermal growth factor receptor (EGFR) positivity with the various histomorphological factors such as tumour size, nuclear grade, histological grade and mitoses. Growth fraction measured by Ki67 monoclonal antibody varied from 3.6 to 73.7 percent. AgNOR counts ranged from 1.2 to 16.9 dots per tumour cell nucleus with a mean of 6.26 dots. EGFR positivity was seen in 66.7% of cases. Ki67 score correlated with all prognostic variables studied except the presence of axillary metastases. AgNOR counts correlated with size of tumour, axillary lymph-node metastases and Ki67 score but no correlation was seen with histologic or nuclear grade. EGFR positivity correlated strongly with size of the tumour and weakly with Ki67 score, AgNOR counts and mitoses.


How to cite this article:
Gupta G, Datta B, Bose S, Joshi K. Correlation of the growth fraction, nucleolar organizer region counts and epidermal growth factor receptor with histomorphological prognostic criteria in breast cancer. Indian J Pathol Microbiol 1997;40:3-10


How to cite this URL:
Gupta G, Datta B, Bose S, Joshi K. Correlation of the growth fraction, nucleolar organizer region counts and epidermal growth factor receptor with histomorphological prognostic criteria in breast cancer. Indian J Pathol Microbiol [serial online] 1997 [cited 2020 Jan 20 ];40:3-10
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=1997;volume=40;issue=1;spage=3;epage=10;aulast=Gupta;type=0