Indian Journal of Pathology and Microbiology


Year
: 2006  |  Volume : 49  |  Issue : 3  |  Page : 352--6

Histopathological changes in gastric mucosa colonized by H. pylori.


A Kumar, R Bansal, Ved Prakash Pathak, S Kishore, Praffull K Karya 
 Department of Pathology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun

Correspondence Address:
A Kumar
Department of Pathology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun

Helicobacter pylori (H. pylori), infection has been linked to acute and chronic gastritis, non-ulcer-dyspepsia, peptic ulcer, gastric adenocarcinoma and gastric non-Hodgkin«SQ»s lymphoma of mucosa-associated lymphoid tissue (MALT). The epithelial changes in H. pylori colonized gastric mucosa are easy to recognize in routine Haematoxylin & Eosin stained sections and are so distinctive that they can serve as a helpful histological indicator for the presence of H. pylori in gastric biopsies. The histopathology of seventy-five gastric biopsies showing colonization by H. pylori was studied. Histologically, the H. pylori colonized gastric epithelium showed characteristic changes that were topographically related to the bacteria. These changes included irregular surface, epithelial pits, individual cell dropout and microerosion, which were specific for H. pylori colonization. These were absent in areas not colonized by H. pylori and in 20 consecutive H. pylori negative gastric biopsies seen during the same study period. As specific treatment for H. pylori infection is available, identification of H. pylori colonization in gastric biopsies should be attempted in all cases of gastritis, peptic ulcers and non-ulcer-dyspepsia.


How to cite this article:
Kumar A, Bansal R, Pathak VP, Kishore S, Karya PK. Histopathological changes in gastric mucosa colonized by H. pylori. Indian J Pathol Microbiol 2006;49:352-6


How to cite this URL:
Kumar A, Bansal R, Pathak VP, Kishore S, Karya PK. Histopathological changes in gastric mucosa colonized by H. pylori. Indian J Pathol Microbiol [serial online] 2006 [cited 2020 Sep 26 ];49:352-6
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2006;volume=49;issue=3;spage=352;epage=6;aulast=Kumar;type=0