Indian Journal of Pathology and Microbiology


Year
: 2007  |  Volume : 50  |  Issue : 1  |  Page : 75--7

Immunophenotypic patterns in precursor T-cell neoplasm.


R Gupta, S Naseem, R Kashyap, S Nityanand 
 Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebarelli Road, Lucknow

Correspondence Address:
R Gupta
Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebarelli Road, Lucknow

T-cell lymphoproliferative disorders are a heterogeneous group of lymphoid neoplasm that can mimic both benign conditions and non-hematopoietic tumors. In routine clinical practice, morphology and immunophenotyping forms the basis of their diagnosis. In this retrospective analysis, we evaluate the utility of flow cytometric immunophenotyping patterns in diagnosis of precursor T-cell neoplasm. Aberrant expression of T-cell antigens was found in all the cases of precursor T-cell neoplasm. The residual normal T-lymphocytes, identifiable in majority of cases, were found to be useful in evaluation of quantitative differences in antigen expression by leukemic cells. A careful analysis of flow cytometric immunophenotyping data can provide additional information which is useful for diagnosis of precursor T-cell neoplasm. This information can be further utilized for analysis of minimal residual disease in these tumors.


How to cite this article:
Gupta R, Naseem S, Kashyap R, Nityanand S. Immunophenotypic patterns in precursor T-cell neoplasm. Indian J Pathol Microbiol 2007;50:75-7


How to cite this URL:
Gupta R, Naseem S, Kashyap R, Nityanand S. Immunophenotypic patterns in precursor T-cell neoplasm. Indian J Pathol Microbiol [serial online] 2007 [cited 2019 Oct 20 ];50:75-7
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2007;volume=50;issue=1;spage=75;epage=7;aulast=Gupta;type=0