Indian Journal of Pathology and Microbiology


Year
: 2007  |  Volume : 50  |  Issue : 1  |  Page : 78--81

Pattern of chromosomal abnormalities in adult acute lymphoblastic leukemia.


S Khalid, M Usman, Salman Naseem Adil, A Ayub, M Khurshid 
 Department of Pathology, Aga Khan University Hospital, Karachi

Correspondence Address:
S Khalid
Department of Pathology, Aga Khan University Hospital, Karachi

OBJECTIVES: To study the pattern of chromosomal abnormalities in adult patients with acute lymphoblastic leukemia. STUDY DESIGN: A retrospective study. Place and duration of study: January 1998 to June 2005 at the Cytogenetics department, Aga Khan University Hospital, Karachi. PATIENTS AND METHODS: A retrospective analysis of cytogenetic studies was carried out in patients who were diagnosed as ALL and were more than 15 years of age. Cytogenetic analysis was performed using a trypsin-Giemsa banding technique. Karyotypes were interpreted using International System for Cytogenetics Nomenclature (1995) criteria. RESULTS: The requests were received for cytogenetic analysis of bone marrow specimens in 69 patients who were diagnosed as ALL. Cytogenetic results were available in 62 patients; out of which 51 were males and 11 were females. 44 patients (70%) were found to have a normal karyotype. In 18 patients (29%), abnormal karyotype was found. CONCLUSION: Cytogenetic studies should be part of the initial work up of every patient with ALL. Larger scale studies will help refine our understanding of the less common chromosomal patterns and conduct multivariate analysis to define the relative prognostic value of karyotypic results.


How to cite this article:
Khalid S, Usman M, Adil SN, Ayub A, Khurshid M. Pattern of chromosomal abnormalities in adult acute lymphoblastic leukemia. Indian J Pathol Microbiol 2007;50:78-81


How to cite this URL:
Khalid S, Usman M, Adil SN, Ayub A, Khurshid M. Pattern of chromosomal abnormalities in adult acute lymphoblastic leukemia. Indian J Pathol Microbiol [serial online] 2007 [cited 2019 Sep 17 ];50:78-81
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2007;volume=50;issue=1;spage=78;epage=81;aulast=Khalid;type=0