Year : 2008 | Volume
: 51 | Issue : 2 | Page : 261--262
Fallopian tube carcinoma
Swami Sunil Yogiraj, Kulkarni Pradeep Vasantrao, Sonwane Bharat Ranganthrao
Department of Pathology, Swami Ramanand Teerth Rural Medical College and Hospital, Ambajogai, Beed - 431 517, Maharashatra, India
Swami Sunil Yogiraj
Bhagwanbaba Chowk, Gitta road, Ambajogai, Beed - 431 517, Maharashatra
Primary adenocarcinoma of Fallopian tube is a rare gynecological malignancy affecting women in the fifth and sixth decades of their lives. The rarity of this type of carcinoma has prompted reports of individual cases rather than publication of a large series.
One such case is reported in a 50-year-old nulliparous post-menopausal female. The age, low fertility index and presentation of the disease are in accordance with previous reports in the literature. The present case also fulfills the diagnostic criteria«SQ»s applied to this tumor.
|How to cite this article:|
Yogiraj SS, Vasantrao KP, Ranganthrao SB. Fallopian tube carcinoma.Indian J Pathol Microbiol 2008;51:261-262
|How to cite this URL:|
Yogiraj SS, Vasantrao KP, Ranganthrao SB. Fallopian tube carcinoma. Indian J Pathol Microbiol [serial online] 2008 [cited 2020 Jul 9 ];51:261-262
Available from: http://www.ijpmonline.org/text.asp?2008/51/2/261/41679
The first genuine case report of primary carcinoma of Fallopian tube was attributed to Orthmann, in 1888.  Primary adenocarcinoma of Fallopian tube represents less than 1% of all gynecological malignancies affecting women in the fifth and sixth decades of their lives.  The incidence varies from 0.16 to 1.6% with an average of 0.3%.  The low fertility index is usually associated with this neoplasm. 
For its diagnosis, the main tumor mass must be confined to the tube with demonstrable carcinoma-in-situ changes in the adjacent mucosa and the uterus and the ovaries should be normal.
We are reporting a case of primary adenocarcinoma of Fallopian tube (papillary variety) in a post-menopausal nulliparous woman.
A 50-year-old nulliparous post-menopausal female was admitted for complaints of spotting since 1 year. Clinical and relevant investigations revealed a left-sided, probably tubo-ovarian mass. A total abdominal hysterectomy with bilateral salpingo-oopherectomy was performed. The iliac and para-aortic lymph nodes were not enlarged.
On gross examination [Figure 1], the ampullary portion of left Fallopian tube for a length of 3 cm was dilated with a thinned-out wall. It contained a large friable mass with papillary processes.
Histologically, multiple sections from left Fallopian tube showed many papillae covered by a stratified layer of cells [Figure 2]. The cells had moderately granular pink cytoplasm with hyperchromatic, pleomorphic nuclei and numerous mitoses. Small islands were seen in the fibrovascular core and in the wall, splaying the smooth muscle bundles apart. Adjacent carcinoma in situ change was also noted. There was infiltration of the tubal wall. There was no evidence of psammoma bodies in these sections.
Sections from ovaries, endometrium, cervix and right-sided Fallopian tube were studied and showed normal histology.
A diagnosis of primary papillary adenocarcinoma of left Fallopian tube was made. The patient was referred to a nearby cancer institute and was then lost to further follow-up.
Primary Fallopian tube carcinoma represents the rarest of reproductive tract malignancy in females. The age for fallopian tube carcinoma is 50 years in the present study, which is comparable to all other studies [Table 1]. ,,,,,
The duration of symptoms ranges from 3 days to a few years and patients with abdominal pain seek medical attention earlier than those with vaginal discharge or menstrual problems.  This may imply that primary carcinoma of Fallopian tube in our present case became symptomatic later in the course of the disease and perhaps had a slower rate of spread. The low fertility index is associated with this neoplasm (71%),  which is true in our case. Thus, the clinical features were comparable to other studies. ,,
Owing to its rarity, stringent diagnostic criteria have to be adopted:
Main tumor mass to be confined to the tube with demonstrable carcinoma-in-situ changes in the adjacent mucosa.Uterus and ovaries should be normal.
These criteria were fulfilled in our case.
|1||Hanton EM, Malkasian GD Jr, Dahlin DC, Pratt JH. Primary carcinoma of the fallopian tube. Am J Obstet Gynecol 1996;94:832-9.|
|2||Eddy GL, Copeland LJ, Gershenson DM, Atkinson EN, Wharton JT, Rutledge FN. Fallopian tube carcinoma. Obstet Gynecol 1984;64:546-52.|
|3||Boutselis JB, Thompson JN. Clinical aspects of primary carcinoma of the Fallopian tube: A clinical study of 14 cases. Am J Obstet Gynecol 1971;3:98-101.|
|4||Raju KS, Barker GH, Wiltshaw E. Primary carcinoma of fallopian tube: Report of 22 cases. Br J Obstet Gynecol 1981;88:1124-9.|
|5||McMurray EH, Jacobs AJ, Perez CA, Camel HM, Kao MS, Galakatos A. Carcinoma of fallopian tube-management and sites of failure. Cancer 1986;58:2070-5.|
|6||Podratz KC, Podczaski ES, Gaffey TA, O'Brien PC, Schray MF, Malkasian GD Jr. Primary carcinoma of fallopian tube. Am J Obstet Gynecol 1986;154:1319-26.|
|7||Vaideeswar P, Desai MS, Prabhat DP, Desai AP. Fallopian tube carcinoma: A report of two cases. Indian J Pathol Microbiol 1997;40:397-9.|