Indian Journal of Pathology and Microbiology

CASE REPORT
Year
: 2008  |  Volume : 51  |  Issue : 4  |  Page : 512--514

Endometrial intraepithelial carcinoma: A case report and brief review


Manisha Ram1, Minakshi Bharadwaj2, Rajbala Yadav2 
1 Department of Cellular Pathology, The Princess Alexandra Hospital, Harlow, Essex CM20 1QX, United Kingdom
2 Department of Pathology, Dr. Ram Manohar Lohia Hospital, New Delhi, India

Correspondence Address:
Manisha Ram
85, Wedgewood Drive, Church Langley, Harlow, CM17 9PY
United Kingdom

This case report describes the precursor lesion of uterine papillary serous carcinoma (UPSC). A 65-year-old post-menopausal female presented with prolapse and vaginal discharge and underwent a hysterectomy revealing an atrophic endometrium, highly atypical endometrial glands, the lining cells of which showed pseudostratification, hobnailing, a high nuclear to cytoplasmic ratio, and prominent nucleoli. A p53 immunoreactivity score of 8 and a MIB-1 index of 80% was obtained leading to a diagnosis of endometrial intraepithelial carcinoma (EIC). Since serous EIC is commonly associated with extra-uterine serous carcinoma, it is a uniquely aggressive precursor lesion. Molecular studies support the hypothesis that EIC is a precursor of both uterine and extra-uterine invasive serous carcinomas. This is why the treatment protocol for EIC cases is total abdominal hysterectomy (TAH), accompanied by a staging procedure. In our patient, EIC was limited to the endometrium; associated with an excellent clinical outcome.


How to cite this article:
Ram M, Bharadwaj M, Yadav R. Endometrial intraepithelial carcinoma: A case report and brief review.Indian J Pathol Microbiol 2008;51:512-514


How to cite this URL:
Ram M, Bharadwaj M, Yadav R. Endometrial intraepithelial carcinoma: A case report and brief review. Indian J Pathol Microbiol [serial online] 2008 [cited 2020 Mar 30 ];51:512-514
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2008;volume=51;issue=4;spage=512;epage=514;aulast=Ram;type=0