Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2009  |  Volume : 52  |  Issue : 1  |  Page : 6--9

CD20 positivity in classical Hodgkin俟Q製 lymphoma: Diagnostic challenge or targeting opportunity


Muhammad Abrar Barakzai, Shahid Pervez 
 Department of Pathology/Microbiology, Section of Histopathology, Aga Khan University Hospital, Karachi, Pakistan

Correspondence Address:
Muhammad Abrar Barakzai
Department of Pathology and Microbiology, Section of Histopathology, Aga Khan University, Hospital, Stadium Road, P.O. Box 3500, Karachi 74800
Pakistan

Background: It is now well established that Hodgkin cells are clonal B cells with a CD30 and CD15 phenotype. However, on immunohistochemistry, in our experience and the experience of others, CD20 positivity in an otherwise typical classical Hodgkin俟Q製 Lymphoma is not uncommon and if associated with CD15 negativity poses a potential diagnostic trap and is likely to be called B-NHL. Objective: To assess the frequency of B-cell related antigens CD20 and CD79a in classical Hodgkin俟Q製 Lymphoma. Materials and Methods: A total of 91 consecutive cases of classical Hodgkin俟Q製 Lymphoma were analyzed for co-expression of CD20 and CD79a. Both males and females of all ages were included in this study. All cases of nodular lymphocyte predominant Hodgkin俟Q製 Lymphoma were excluded. All the cases were stained with a panel of antibodies including LCA, CD20, CD79a, CD30, CD15, CD3, EMA and Alk. Protein. Results: All 91 cases of classical Hodgkin俟Q製 Lymphoma showed negativity for LCA and positivity for CD30. Eighteen cases (19.8%) showed distinct membrane staining with CD20 in most of the large atypical cells. However, out of these, only 7 cases (7.7%) showed CD79a co-expression, which was largely focal. CD15 negativity with CD20 positivity was seen in 7 (7.7%) cases of otherwise typical classical Hodgkin俟Q製 Lymphoma. Conclusions/Recommendations: CD20 expression is frequent in classical Hodgkin俟Q製 Lymphoma and our results are in consensus with reported literature on this subject. In these cases, LCA negativity of large cells was extremely useful in clinching the right diagnosis.


How to cite this article:
Barakzai MA, Pervez S. CD20 positivity in classical Hodgkin's lymphoma: Diagnostic challenge or targeting opportunity.Indian J Pathol Microbiol 2009;52:6-9


How to cite this URL:
Barakzai MA, Pervez S. CD20 positivity in classical Hodgkin's lymphoma: Diagnostic challenge or targeting opportunity. Indian J Pathol Microbiol [serial online] 2009 [cited 2020 Sep 18 ];52:6-9
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=1;spage=6;epage=9;aulast=Barakzai;type=0