Indian Journal of Pathology and Microbiology

: 2011  |  Volume : 54  |  Issue : 4  |  Page : 853--854

Differential diagnosis of oncocytic pleomorphic adenoma

Shaodong Yang 
 Department of Oral Histopathology, Hainan Medical College, Longhua District, Haikou, China

Correspondence Address:
Shaodong Yang
Department of Oral Histopathology, Hainan Medical College, 3 Xueyuan Road, Longhua District, Haikou

How to cite this article:
Yang S. Differential diagnosis of oncocytic pleomorphic adenoma.Indian J Pathol Microbiol 2011;54:853-854

How to cite this URL:
Yang S. Differential diagnosis of oncocytic pleomorphic adenoma. Indian J Pathol Microbiol [serial online] 2011 [cited 2020 Jun 5 ];54:853-854
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I read with great interest the recent case report by Mariano et al. [1] The authors report a unique case of oncocytic pleomorphic adenoma (PA) of the parotid gland. However, the authors have omitted an important differential diagnosis, namely, oncocytic epithelial-myoepithelial carcinoma (EMC).

Oncocytic EMC was a recently described variant of EMC and this entity should be included in the differential diagnosis of oncocytic tumors of salivary glands. [2],[3],[4] With reference to this case reported by Mariano et al., [1] a biphasic nature of the tumor was confirmed by histopathology and immunohistochemistry. Both oncocytic PA and oncocytic EMC should be considered. Distinguishing features from PA include documentation of invasion and the absence of chondromyxoid stroma in EMC. However, this case was devoid of chondromyxoid stroma, which was usually seen in previously reported oncocytic PA. [5] Although an evident capsule was noted by the authors, it should be kept in mind that at least partial encapsulation in EMC is relatively common and complete encapsulation with minimal invasion was seen in 19.7% EMCs. [3] Therefore, a careful examination of invasion is required to exclude oncocytic EMC before a diagnosis oncocytic PA is made.


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5Di Palma S, Lambros MB, Savage K, Jones C, Mackay A, Dexter T, et al. Oncocytic change in pleomorphic adenoma: Molecular evidence in support of an origin in neoplastic cells. J Clin Pathol 2007;60:492-9.