Indian Journal of Pathology and Microbiology

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Year
: 2013  |  Volume : 56  |  Issue : 4  |  Page : 470-

Extensively calcified cystic extraventricular neurocytoma


Aparna Govindan1, Vijayan Peettakkandy2, Jacob Paul Alapatt2,  
1 Department of Pathology, Govt. Medical College, Kozhikode, Kerala, India
2 Department of Neurosurgery, Govt. Medical College, Kozhikode, Kerala, India

Correspondence Address:
Aparna Govindan
Department of Pathology, Govt. Medical College, Kozhikode - 673 008, Kerala
India




How to cite this article:
Govindan A, Peettakkandy V, Alapatt JP. Extensively calcified cystic extraventricular neurocytoma.Indian J Pathol Microbiol 2013;56:470-470


How to cite this URL:
Govindan A, Peettakkandy V, Alapatt JP. Extensively calcified cystic extraventricular neurocytoma. Indian J Pathol Microbiol [serial online] 2013 [cited 2020 Aug 6 ];56:470-470
Available from: http://www.ijpmonline.org/text.asp?2013/56/4/470/125381


Full Text

A 29-years-old female presented with complaints of occipital headache and blurring of vision of 6 months duration. Cranial MR Imaging showed an intra-axial, cystic lesion in the right parieto-occipital region, with a T1 isointense [Figure 1]a) and T2 hypointense [Figure 1]b) focally enhancing mural nodule on T1W contrast image (A: inset), without any communication to the lateral ventricle. Per-operatively, the cyst contained clear yellowish fluid and a calcified, friable, relatively avascular nodule in its depth. Histopathological examination showed a hypocellular tumor with extensive calcification [Figure 1]c: H&E × 40, Figure 1d: H&E × 100). The tumor cells were uniform with round to oval nuclei having fine speckled chromatin and interspersed fibrillary areas [Figure 1]f: H&E × 400). The tumor cells were immunopositive for the neuronal marker, synaptophysin [Figure 1]e × 100, [Figure 1] Finset × 400).{Figure 1}

Extraventricular neurocytomas are rare neurocytic neoplasms located outside the ventricular system with histological features similar to central neurocytomas. Giangaspero et al in 1997 first described extraventricular neurocytic neoplasms in a report of 11 cases. [1],[2] They were first included as a separate entity in the 2007 WHO classification of tumors of the central nervous system as a variant of central neurocytoma. They are known to show a cyst-mural nodule configuration, lower cellularity, and ganglionic differentiation, more commonly than their intraventricular counterparts. A close histopathological differential diagnosis is oligodendroglioma. Neuronal nature of these tumors is confirmed immunohistochemically by positivity for synaptophysin. In the present case, the circumscription of the tumor, cystic nature with a mural nodule, and positivity for synaptophysin, differentiated it from oligodendroglioma.[3].

References

1Brat DJ, Scheithauer BW, Eberhart CG, Burger PC: Extraventricular Neurocytomas: Pathologic features and clinical outcome. Am J Surg Pathol 2001;25:1252-60.
2Choi H, Park SH, Kim DG, Paek SH. Atypical extraventricular neurocytoma. J Korean Neurosurg Soc 2011;50:381-4.
3Figarella-Branger D, Söylemezoglu F, Burger PC. Central neurocytoma and extraventricular neurocytoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, (editors) WHO classification of tumors of the Central Nervous System. 4th ed. Lyon: International Agency for Research on Cancer;2007 pp 106-9.