Year : 2014 | Volume
: 57 | Issue : 4 | Page : 529-
From Editor's desk
Editor-in Chief, IJPM, Professor and Head, Department of Pathology, MLN Medical College, Allahabad, Uttar Pradesh, India
Editor-in Chief, IJPM, Professor and Head, Department of Pathology, MLN Medical College, Allahabad, Uttar Pradesh
|How to cite this article:|
Misra V. From Editor's desk
.Indian J Pathol Microbiol 2014;57:529-529
|How to cite this URL:|
Misra V. From Editor's desk
. Indian J Pathol Microbiol [serial online] 2014 [cited 2020 Jun 6 ];57:529-529
Available from: http://www.ijpmonline.org/text.asp?2014/57/4/529/142630
With immense pleasure, I present before you the last issue of IJPM 2014. The issue has been published well in time. This can be attributed to the constant support, active interest, and hard work of all the editorial board members and reviewers. I cannot underestimate the efforts put in by the authors in doing excellent research work and preparing the manuscripts for publication in this journal.
Technology is constantly changing, and newer advancements are being made to make our results more accurate, sensitive, and specific for diagnosing a disease. Besides, the researchers are working hard to find out the etiopathogenesis of various diseases and the role played by various cellular elements in the progression of the disease.
Breast cancer is one of the leading causes of mortality in Indian women. In last decade, expression of a number of hormonal and other markers in epithelial cells has been studied in detail. Study of these hormonal markers has become mandatory for the correct diagnosis, treatment, and prognosis of patients with breast carcinoma. Stromal markers are now emerging as novel markers in assessing the prognosis of invasive breast cancer and have not been studied extensively till date. A better understanding of stromal contribution to cancer progression will identify specific signals that promote growth, dedifferentiation, invasion, and ectopic survival of tumor cells and may eventually result in the identification of new therapeutic targets for future treatment. The study by Sayantan Jana et al. in this issue explains in detail the role of stromal CD10 expression in breast cancer pathogenesis.
Stromal and soft tissue tumors may present with a deceptive morphology and sometimes it becomes very difficult to accurately classify them or differentiate a well-differentiated tumor from a benign/reactive lesion. Newer markers are being constantly identified for the correct diagnosis. Rizky Putri et al. evaluated that murine double minute 2 (MDM2) overexpression can be used as a useful adjunct to histology for differentiating well-differentiated liposarcoma from large lipoma. Overexpression of MDM2 also appears to be related with Ki67 proliferation index. Rekhi et al. have described the role of cyclinD1 and p16INK4 in identification of CD10 negative endometrial stromal sarcoma which may be misdiagnosed as undifferentiated sarcomas.
Tuberculosis is a common infection in many of the developing countries. It may present with diverse clinical presentation, and sometimes, the diagnosis depends on identification of the infecting organism that is not easy due to low yield of acid-fast bacilli in tissue sections. Kohli et al. have studied immunohistochemical localization of tubercle bacilli or their components that may persist in the granulomas, but have lost the property of staining with acid-fast stain. They have found it to be a simple and sensitive technique for localization of tubercle bacilli and their components on tissue sections along with conventional Ziehl Neelsen staining.
I hope, the articles published in this issue will be of interest to both teaching and practicing pathologists and microbiologists and will help postgraduates in enhancing their knowledge and field of research.
With best wishes