Indian Journal of Pathology and Microbiology

CASE REPORT
Year
: 2015  |  Volume : 58  |  Issue : 2  |  Page : 214--216

Primary Merkel cell carcinoma of the oral mucosa in a young adult male: Report of a rare case


Shravasti Roy1, Indranil Das1, Ayandip Nandi2, Rakesh Roy1 
1 Department of Pathology and Medical Oncology, Saroj Gupta Cancer Centre and Research Institute, Kolkata, West Bengal, India
2 Medical College, Kolkata, West Bengal, India

Correspondence Address:
Dr. Ayandip Nandi
48/7, Patuapara Lane, P.O. Serampore, Hooghly - 712 201, West Bengal
India

Merkel cell carcinoma (MCC) is a highly aggressive neoplasm of skin with neuroendocrine differentiation. Primary MCC of the oral mucosa is exceedingly rare and even more unresponsive to therapy. A 15-year-old male presents with gradually increasing painless swelling in right side of the floor of mouth for 6 weeks. Computed tomography of head and neck region showed globular mass (4.6 cm × 1.7 cm) involving right side of the floor of mouth. Fine-needle aspiration from the upper deep cervical node suggested small round cell tumor. A trucut biopsy showed mass composed of trabeculae and nests of tumor cells with high N:C ratio, granular speckled chromatin, scanty to moderate amount of clear vacuolated cytoplasm. Cells were immunoreactive for cytokeratin-20, CD56, c-kit, CD99 and negative for p63, thyroid-transcription factor-1, CDX2, synaptophysin, neuron-specific enolase. Patient was started on chemotherapy with cyclophosphamide, doxorubicin and vincristine. The mass regressed in size and patient underwent wide local excision with pull-through approach. Patient is currently under combined chemoradiation regime and doing well.


How to cite this article:
Roy S, Das I, Nandi A, Roy R. Primary Merkel cell carcinoma of the oral mucosa in a young adult male: Report of a rare case.Indian J Pathol Microbiol 2015;58:214-216


How to cite this URL:
Roy S, Das I, Nandi A, Roy R. Primary Merkel cell carcinoma of the oral mucosa in a young adult male: Report of a rare case. Indian J Pathol Microbiol [serial online] 2015 [cited 2020 Aug 13 ];58:214-216
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2015;volume=58;issue=2;spage=214;epage=216;aulast=Roy;type=0